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Safety and Outcomes of Routine Endovascular Thrombectomy in Large Artery Occlusion Recorded in the SITS Register: An Observational Study

2021Journal article Open access
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dc.contributor.authorAhmed, N.
dc.contributor.authorMazya, M.
dc.contributor.authorPaiva Nunes, A
dc.contributor.authorMoreira, T
dc.contributor.authorOllikainen, JP
dc.contributor.authorEscudero‐Martinez, I
dc.contributor.authorBigliardi, G
dc.contributor.authorDorado, L
dc.contributor.authorDávalos, A
dc.contributor.authorEgido, JA
dc.contributor.authorTassi, R
dc.contributor.authorStrbian, D
dc.contributor.authorZini, A
dc.contributor.authorNichelli, P
dc.contributor.authorHerzig, R
dc.contributor.authorJurák, L
dc.contributor.authorHurtikova, E
dc.contributor.authorTsivgoulis, G
dc.contributor.authorPeeters, A
dc.contributor.authorNevšímalová, M
dc.contributor.authorBrozman, M
dc.contributor.authorCavallo, R
dc.contributor.authorLees, KR
dc.contributor.authorMikulik, R
dc.contributor.authorToni, D
dc.contributor.authorHolmin, S
dc.date.accessioned2022-12-29T12:55:49Z
dc.date.available2022-12-29T12:55:49Z
dc.date.issued2021
dc.description.abstractBackground and objective: We aimed to evaluate the safety and outcomes of thrombectomy in anterior circulation acute ischaemic stroke recorded in the SITS-International Stroke Thrombectomy Register (SITS-ISTR) and compare them with pooled randomized controlled trials (RCTs) and two national registry studies. Methods: We identified centres recording ≥10 consecutive patients in the SITS-ISTR with at least 70% of available modified Rankin Scale (mRS) at 3 months during 2014-2019. We defined large artery occlusion as intracranial internal carotid artery, first and second segment of middle cerebral artery and first segment of anterior cerebral artery. Outcome measures were functional independence (mRS score 0-2) and death at 3 months and symptomatic intracranial haemorrhage (SICH) per modified SITS-MOST. Results: Results are presented in the following order: SITS-ISTR, RCTs, MR CLEAN Registry and German Stroke Registry (GSR). Median age was 73, 68, 71 and 75 years; baseline NIHSS score was 16, 17, 16 and 15; prior intravenous thrombolysis was 62%, 83%, 78% and 56%; onset to reperfusion time was 289, 285, 267 and 249 min; successful recanalization (mTICI score 2b or 3) was 86%, 71%, 59% and 83%; functional independence at 3 months was 45.5% (95% CI: 44-47), 46.0% (42-50), 38% (35-41) and 37% (35-41), respectively; death was 19.2% (19-21), 15.3% (12.7-18.4), 29.2% (27-32) and 28.6% (27-31); and SICH was 3.6% (3-4), 4.4% (3.0-6.4), 5.8% (4.7-7.1) and not available. Conclusion: Thrombectomy in routine clinical use registered in the SITS-ISTR showed safety and outcomes comparable to RCTs, and better functional outcomes and lower mortality than previous national registry studies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Intern Med . 2021 Sep;290(3):646-654.pt_PT
dc.identifier.doi10.1111/joim.13302pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4342
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectArteriespt_PT
dc.subjectHumanspt_PT
dc.subjectBrain Ischemia* / surgerypt_PT
dc.subjectHSJ UCVpt_PT
dc.subjectEndovascular Procedures
dc.subjectIntracranial Hemorrhages
dc.subjectRandomized Controlled Trials as Topic
dc.subjectRetrospective Studies
dc.subjectStroke
dc.subjectTreatment Outcome
dc.titleSafety and Outcomes of Routine Endovascular Thrombectomy in Large Artery Occlusion Recorded in the SITS Register: An Observational Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage654pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage646pt_PT
oaire.citation.titleJournal of Internal Medicinept_PT
oaire.citation.volume290pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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