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Seroprevalence of SARS-CoV-2 Infection in Portugal in May-July 2020: Results of the First National Serological Survey (ISNCOVID-19)

2021-02-01Journal article Open access
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dc.contributor.authorKislaya, I
dc.contributor.authorGonçalves, P
dc.contributor.authorBarreto, M
dc.contributor.authorSousa, R
dc.contributor.authorGarcia, AC
dc.contributor.authorMatos, R
dc.contributor.authorGuiomar, R
dc.contributor.authorRodrigues, AP
dc.contributor.authorDias, A
dc.date.accessioned2021-04-14T18:43:58Z
dc.date.available2021-04-14T18:43:58Z
dc.date.issued2021-02-01
dc.description.abstractIntroduction: The aim of this study was to estimate and describe the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific antibodies (immunoglobulin M and/or immunoglobulin G) in Portugal in May-July 2020. Material and methods: A cross-sectional seroepidemiological survey was developed after the peak of the first epidemic wave on a sample of 2301 Portuguese residents, aged 1 year or older. Survey sample was selected using a two-stage stratified non-probability sampling design (quota sampling). SARS-CoV-2 immunoglobulin M and immunoglobulin G antibodies were measured in serum samples by enzyme-linked immunosorbent assay. Seroprevalence estimates of immunoglobulin M and/or immunoglobulin G and 95% confidence intervals were stratified by sex, age group, health region and education. Results: Overall, seroprevalence was 2.9% (95% confidence interval: 2.0% - 4.2%). Higher prevalence rates were observed in male (4.1%, 95% confidence interval: 2.6% - 6.6%) and those with secondary education (6.4%, 95% confidence interval: 3.2% - 12.5%). Differences in seroprevalence by age group and region were not statistically significant. Discussion: The estimated seroprevalence of SARS-CoV-2 was higher than the cumulative incidence reported by the National Surveillance System but far from necessary to reach herd immunity. Conclusion: Our results support limited extent of infection by SARS-CoV-2 in the study population possibly due to early lockdown measures implemented in Portugal and support the need to continue monitoring of SARS-CoV-2 seroprevalence in order to increase our knowledge about the evolution of the epidemic and to estimate the proportion of the susceptible population over time.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Med Port 2021 Feb;34(2):87-94pt_PT
dc.identifier.doi10.20344/amp.15122pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3653
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.publisherCentro Editor Livreiro da Ordem dos Médicospt_PT
dc.subjectAdolescentpt_PT
dc.subjectAdultpt_PT
dc.subjectAge Distributionpt_PT
dc.subjectAgedpt_PT
dc.subjectAntibodies, Viralpt_PT
dc.subjectCOVID-19pt_PT
dc.subjectChildpt_PT
dc.subjectChild, Preschoolpt_PT
dc.subjectConfidence Intervalspt_PT
dc.subjectCross-Sectional Studiespt_PT
dc.subjectEducational Statuspt_PT
dc.subjectEpidemicspt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectImmunoglobulin Gpt_PT
dc.subjectImmunoglobulin Mpt_PT
dc.subjectInfantpt_PT
dc.subjectInfant, Newbornpt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPortugalpt_PT
dc.subjectPrevalencept_PT
dc.subjectSARS-CoV-2pt_PT
dc.subjectSeroepidemiologic Studiespt_PT
dc.subjectSex Distributionpt_PT
dc.subjectYoung Adultpt_PT
dc.subjectHDE PEDpt_PT
dc.titleSeroprevalence of SARS-CoV-2 Infection in Portugal in May-July 2020: Results of the First National Serological Survey (ISNCOVID-19)pt_PT
dc.title.alternativeSeroprevalência da Infecção por SARS-CoV-2 em Portugal em Maio-Julho de 2020: Resultados do Primeiro Inquérito Serológico Nacional (ISNCOVID-19)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage94pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage87pt_PT
oaire.citation.titleActa medica portuguesapt_PT
oaire.citation.volume34pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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