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Usefulness of TNFR1 As Biomarker of Intracranial Aneurysm in Patients with Spontaneous Subarachnoid Hemorrhage

2019-11-05Journal article Open access
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dc.contributor.authorTorres, R
dc.contributor.authorMancha, F
dc.contributor.authorBustamante, A
dc.contributor.authorCanhao, P
dc.contributor.authorFragata, I
dc.contributor.authorMontaner, J
dc.date.accessioned2020-01-14T15:50:23Z
dc.date.available2020-01-14T15:50:23Z
dc.date.issued2019-11-05
dc.description.abstractAim: To determine the utility of TNF-α receptor (TNFR1) as a biomarker for the presence of aneurysms in patients with acute subarachnoid hemorrhage (SAH). Patient & methods: This is a prospective study in patients with acute spontaneous SAH. Arterial blood from catheter near aneurysm and peripheral venous blood samples are collected. TNFR1 levels were analyzed in patients with and without aneurysm. Results: 80 patients were included, 58 were analyzed. 41 patients (70.7%) had an aneurysm. Venous TNFR1 levels >1658 pg/ml had 46.3% sensitivity and 94.1% specificity for aneurysms presence. TNFR1 >1658 pg/ml was also an independent predictor for its presence (odds ratio = 12.03 [1.13-128.16]; p = 0.039). Conclusion: High levels of TNFR1 in peripheral venous blood are associated with the presence of aneurysm in patients with acute SAH.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFuture Sci OA. 2019 Nov 5;6(1):FSO431.pt_PT
dc.identifier.doi10.2144/fsoa-2019-0090pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3399
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFuture Sciencept_PT
dc.subjectCHLC NRADpt_PT
dc.subjectAneurysmpt_PT
dc.subjectBiomarkerpt_PT
dc.subjectSpontaneous Subarachnoid Hemorrhagept_PT
dc.subjectStrokept_PT
dc.subjectTNFR1pt_PT
dc.titleUsefulness of TNFR1 As Biomarker of Intracranial Aneurysm in Patients with Spontaneous Subarachnoid Hemorrhagept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPageFSO431pt_PT
oaire.citation.titleFuture Science OApt_PT
oaire.citation.volume6pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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