Concurrence of Gestational Diabetes and Pre-Gravid Obesity ("Diabesity") in Twin Gestations

Simões, T; Queirós, A; Valdoleiros, S; Marujo, AT; Felix, N; Blickstein, I

http://hdl.handle.net/10400.17/2692

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Abstract(s)

OBJECTIVE: To assess the effect of the concurrence of gestational diabetes mellitus (GDM) and pre-gravid obesity in twin gestations ("diabesity"). METHODS: We compared perinatal outcomes of twin gestation in mothers with GDM and pre-gravid obesity (1.7%), mothers with GDM but with normal BMI (6.2%), and obese mothers without GDM (7.0%). RESULTS: Twin pregnancies with "diabesity" were associated with significantly higher incidence of stillbirth (OR = 6.4; 95%CI = 1.4, 33.4) and existing chronic hypertension (OR = 4.2; 95%CI = 1.2, 14.8) than in GDM pregnancies without obesity, and with births at 33-36 weeks as compared with the other groups. Otherwise, the comparisons showed remarkable similar results in terms of gestational age, birth weight, preeclampsia, cesarean section rate, and fetal-neonatal outcomes. CONCLUSION: It appears that diabesity has a relatively minor effect in twins. If this will be confirmed by other studies, it would be important to elucidate how twins ameliorate the adverse outcomes of diabesity.

Keywords

MAC MED MAF Birth Weight Body Mass Index Cesarean Section/statistics & numerical data Diabetes, Gestational/epidemiology Gestational Age Hypertension/complications Hypertension/epidemiology Obesity/complications Obesity/epidemiology Pre-Eclampsia/epidemiology Pregnancy Pregnancy Complications/epidemiology Pregnancy, Twin Stillbirth/epidemiology