Publication
Sex-Based Differences in the Response to Dexamethasone in Bacterial Meningitis: Analysis of the European Dexamethasone in Adulthood Bacterial Meningitis Study
| dc.contributor.author | Dias, S | |
| dc.contributor.author | Brouwer, M | |
| dc.contributor.author | Beek, D | |
| dc.date.accessioned | 2021-10-04T12:29:53Z | |
| dc.date.available | 2021-10-04T12:29:53Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Inflammatory markers have been found at higher concentrations in women than men with bacterial meningitis. To investigate sex-based differences in the response to dexamethasone, we performed a post hoc analysis of a double-blind, randomised multicentre trial of dexamethasone (10 mg, 4 times daily for 4 days) vs placebo in adults with bacterial meningitis. The primary outcome measure was the Glasgow outcome scale score at 8 weeks and interaction tests were used to examine subgroup differences. Between June 1993 and December 2001, 301 patients (56% male) were randomly assigned to a treatment group: 157 received dexamethasone and 144 placebo. Although dexamethasone reduced the risk of unfavourable outcome to a greater extent in women (relative risk [RR] 0.42, 95% confidence interval [CI] 0.21-0.86, P = .02) than men (RR 0.79, 95% CI 0.41-1.51, P = .55), on interaction testing (ratio of RR women:men 0.53, 95% CI 0.20-1.39, P = .19) patient sex was not a significant modifier of the effect of dexamethasone. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Br J Clin Pharmacol. 2020 Feb;86(2):386-391. | pt_PT |
| dc.identifier.doi | 10.1111/bcp.14163. | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/3862 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | British Pharmacological Society | pt_PT |
| dc.subject | CHLC NEU | pt_PT |
| dc.subject | Adult | pt_PT |
| dc.subject | Female | pt_PT |
| dc.subject | Male | pt_PT |
| dc.subject | Humans | pt_PT |
| dc.subject | Biomarkers | pt_PT |
| dc.subject | Dexamethasone | pt_PT |
| dc.subject | Double-Blind Method | pt_PT |
| dc.subject | Meningitis, Bacterial* / drug therapy | pt_PT |
| dc.subject | Meningitis, Bacterial* / epidemiology | pt_PT |
| dc.title | Sex-Based Differences in the Response to Dexamethasone in Bacterial Meningitis: Analysis of the European Dexamethasone in Adulthood Bacterial Meningitis Study | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 391 | pt_PT |
| oaire.citation.startPage | 386 | pt_PT |
| oaire.citation.title | British Journal of Clinical Pharmacology | pt_PT |
| oaire.citation.volume | 86 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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