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Long-Term Prognostic Impact of CT-Leaman Score in Patients with Non-Obstructive CAD: Results from the COronary CT Angiography EvaluatioN For Clinical Outcomes InteRnational Multicenter (CONFIRM) Study

2017-03-15Journal article Open access
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dc.contributor.authorAndreini, D
dc.contributor.authorPontone, G
dc.contributor.authorMushtaq, S
dc.contributor.authorGransar, H
dc.contributor.authorConte, E
dc.contributor.authorBartorelli, AL
dc.contributor.authorPepi, M
dc.contributor.authorOpolski, M
dc.contributor.authorÓ Hartaigh, B
dc.contributor.authorBerman, D
dc.contributor.authorBudoff, M
dc.contributor.authorAchenbach, S
dc.contributor.authorAl-Mallah, M
dc.contributor.authorCademartiri, Fi
dc.contributor.authorCallister, T
dc.contributor.authorChang, HJ
dc.contributor.authorChinnaiyan, K
dc.contributor.authorChow, B
dc.contributor.authorCury, R
dc.contributor.authorDelago, A
dc.contributor.authorHadamitzky, M
dc.contributor.authorHausleiter, J
dc.contributor.authorFeuchtner, G
dc.contributor.authorKim, YJ
dc.contributor.authorKaufmann, PA
dc.contributor.authorLeipsic, J
dc.contributor.authorLin, FY
dc.contributor.authorMaffei, E
dc.contributor.authorRaff, G
dc.contributor.authorShaw, LJ
dc.contributor.authorVillines, TC
dc.contributor.authorDunning, A
dc.contributor.authorMarques, H
dc.contributor.authorRubinshtein, R
dc.contributor.authorHindoyan, N
dc.contributor.authorGomez, M
dc.contributor.authorMin, JK
dc.date.accessioned2017-12-11T16:32:48Z
dc.date.available2017-12-11T16:32:48Z
dc.date.issued2017-03-15
dc.description.abstractBACKGROUND: Non-obstructive coronary artery disease (CAD) identified by coronary computed tomography angiography (CCTA) demonstrated prognostic value. CT-adapted Leaman score (CT-LeSc) showed to improve the prognostic stratification. Aim of the study was to evaluate the capability of CT-LeSc to assess long-term prognosis of patients with non-obstructive (CAD). METHODS: From 17 centers, we enrolled 2402 patients without prior CAD history who underwent CCTA that showed non-obstructive CAD and provided complete information on plaque composition. Patients were divided into a group without CAD and a group with non-obstructive CAD (<50% stenosis). Segment-involvement score (SIS) and CT-LeSc were calculated. Outcomes were non-fatal myocardial infarction (MI) and the combined end-point of MI and all-cause mortality. RESULTS: Patient mean age was 56±12years. At follow-up (mean 59.8±13.9months), 183 events occurred (53 MI, 99 all-cause deaths and 31 late revascularizations). CT-LeSc was the only multivariate predictor of MI (HRs 2.84 and 2.98 in two models with Framingham and risk factors, respectively) and of MI plus all-cause mortality (HR 2.48 and 1.94 in two models with Framingham and risk factors, respectively). This was confirmed by a net reclassification analysis confirming that the CT-LeSc was able to correctly reclassify a significant proportion of patients (cNRI 0.28 and 0.23 for MI and MI plus all-cause mortality, respectively) vs. baseline model, whereas SIS did not. CONCLUSION: CT-LeSc is an independent predictor of major acute cardiac events, improving prognostic stratification of patients with non-obstructive CAD.pt_PT
dc.description.sponsorshipDr. Min has served on themedical advisory boards Arineta; He is a consultant to Heart Flowand Cardiovascular Research Foundation; and has received research support from GE Healthcare.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Cardiol. 2017 Mar 15;231:18-25pt_PT
dc.identifier.doi10.1016/j.ijcard.2016.12.137pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2820
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAgedpt_PT
dc.subjectCause of Deathpt_PT
dc.subjectComputed Tomography Angiographypt_PT
dc.subjectCoronary Angiographypt_PT
dc.subjectCoronary Artery Diseasept_PT
dc.subjectCoronary Vesselspt_PT
dc.subjectFemalept_PT
dc.subjectFollow-Up Studiespt_PT
dc.subjectGlobal Healthpt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectPredictive Value of Testspt_PT
dc.subjectPrognosispt_PT
dc.subjectProspective Studiespt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectRisk Factorspt_PT
dc.subjectTime Factorspt_PT
dc.subjectRegistriespt_PT
dc.subjectHCC CIRpt_PT
dc.titleLong-Term Prognostic Impact of CT-Leaman Score in Patients with Non-Obstructive CAD: Results from the COronary CT Angiography EvaluatioN For Clinical Outcomes InteRnational Multicenter (CONFIRM) Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage25pt_PT
oaire.citation.startPage18pt_PT
oaire.citation.titleInternational Journal of Cardiologypt_PT
oaire.citation.volume231pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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