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The Influence of Tumor Burden Score and Lymph Node Metastasis on the Survival Benefit of Adjuvant Chemotherapy in Intrahepatic Cholangiocarcinoma.

2025-06Text Open access
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dc.contributor.authorKawashima, Jun
dc.contributor.authorEndo, Yutaka
dc.contributor.authorWoldesenbet, Selamawit
dc.contributor.authorKhalil, Mujtaba
dc.contributor.authorAkabane, Miho
dc.contributor.authorCauchy, François
dc.contributor.authorShen, Feng
dc.contributor.authorMaithel, Shishir
dc.contributor.authorPopescu, Irinel
dc.contributor.authorKitago, Minoru
dc.contributor.authorWeiss, Matthew J
dc.contributor.authorMartel, Guillaume
dc.contributor.authorPulitano, Carlo
dc.contributor.authorAldrighetti, Luca
dc.contributor.authorPoultsides, George
dc.contributor.authorRuzzente, Andrea
dc.contributor.authorBauer, Todd W
dc.contributor.authorGleisner, Ana
dc.contributor.authorPinto Marques, Hugo
dc.contributor.authorGroot Koerkamp, Bas
dc.contributor.authorEndo, Itaru
dc.contributor.authorPawlik, Timothy M
dc.date.accessioned2025-09-26T15:12:47Z
dc.date.available2025-09-26T15:12:47Z
dc.date.issued2025-06
dc.description.abstractIntroduction: While postoperative adjuvant chemotherapy (AC) is generally recommended for intrahepatic cholangiocarcinoma (ICC), its benefit remains debated. This study aimed to identify patients that may benefit from AC following liver resection of ICC. Methods: Patients who underwent liver resection for ICC between 2000 and 2023 were identified from an international multi-institutional database. Individual multivariable Cox models were used to evaluate the interaction between each prognostic factor and the effect of AC on survival. Results: Among 1412 patients, 431 (30.5%) received AC. Both higher tumor burden score (TBS; hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.91-1.00; p = 0.033) and metastatic lymph node status (HR 0.58, 95% CI 0.38-0.89; p = 0.014) demonstrated interactions with the survival benefit from receipt of AC. Interaction plots highlighted how AC was associated with improved survival beyond a TBS of approximately 6. Notably, among 555 (39.3%) patients with TBS <6 and N0 or Nx status, 5-year overall survival (OS) was no different between patients who received AC versus individuals who did not (55.1% [95% CI 48.9-62.1] vs. 58.7% [95% CI 49.8-69.2]; p = 0.900). In contrast, among 857 (60.7%) patients with TBS ≥6 or N1 status, AC was associated with improved 5-year OS (30.7% [95% CI 26.2-36.0] vs. 33.0% [95% CI 26.9-40.5]; p = 0.018). Conclusions: TBS and lymph node status may be useful in a multidisciplinary setting to inform decisions about AC planning for ICC patients following curative-intent resection.eng
dc.identifier.citationAnn Surg Oncol . 2025 Jun;32(6):4341-4351. doi: 10.1245/s10434-025-17013-5.
dc.identifier.doi10.1245/s10434-025-17013-5.
dc.identifier.pmid39962005
dc.identifier.urihttp://hdl.handle.net/10400.17/5184
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHCC CIR
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectHumans
dc.subjectBile Duct Neoplasms* / drug therapy
dc.subjectBile Duct Neoplasms* / mortality
dc.subjectBile Duct Neoplasms* / pathology
dc.subjectBile Duct Neoplasms* / surgery
dc.subjectChemotherapy
dc.subjectAdjuvant / mortality
dc.subjectCholangiocarcinoma* / drug therapy
dc.subjectCholangiocarcinoma* / mortality
dc.subjectCholangiocarcinoma* / pathology
dc.subjectCholangiocarcinoma* / surgery
dc.subjectFollow-Up Studies
dc.subjectHepatectomy* / mortality
dc.subjectLymphatic Metastasis
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectSurvival Rate
dc.subjectTumor Burden*
dc.titleThe Influence of Tumor Burden Score and Lymph Node Metastasis on the Survival Benefit of Adjuvant Chemotherapy in Intrahepatic Cholangiocarcinoma.eng
dc.typetext
dspace.entity.typePublication
oaire.citation.endPage4351
oaire.citation.issue6
oaire.citation.startPage4341
oaire.citation.titleAnnals of Surgical Oncology
oaire.citation.volume32
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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