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Parvovirus B19 Infection Associated with Hemolytic Anemia and Cranial Polyneuropathy

2017-10Journal article Open access
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dc.contributor.authorSequeira, J
dc.contributor.authorCalado, A
dc.contributor.authorDias, M
dc.contributor.authorManita, M
dc.date.accessioned2018-11-28T16:22:33Z
dc.date.available2018-11-28T16:22:33Z
dc.date.issued2017-10
dc.description.abstractParvovirus B19 (PB19) is a common, widespread, small, single-stranded DNA virus which has been linked with a broad spectrum of clinical illnesses, including a variety of neurological complications such as encephalitis, meningitis, myelitis, stroke, cerebellar ataxia, and neuropathy. The authors describe a case of PB19 infection associated with hemolytic anemia and cranial polyneuropathy involving the second and third cranial nerves in a 23-year-old immunocompetent woman. The diagnosis of acute PB19 infection was established with detection of positive DNA and anti-PB19 IgM antibodies in blood samples. Antiganglioside antibody studies were performed and serum anti-GD1b IgG was strongly positive. Further investigation was normal or negative, excluding other infectious or autoimmune disorders. The patient was initially treated with a 5-day course of intravenous immunoglobulin (IGIV). Because of incomplete neurological recovery, methylprednisolone was also administered 7 days after IGIV therapy initiation. Complete resolution of clinical symptoms was observed 3 months after disease onset at follow-up visit, despite the persistence of PB19 DNA and anti-PB19 IgM antibodies in serum 5 months after the initial presentation. Our report provides evidence that PB19 could affect both the central and peripheral nervous system, possibly by triggering an autoimmune mechanism that leads to autoantibody production.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Neurovirol. 2017 Oct;23(5):786-788.pt_PT
dc.identifier.doi10.1007/s13365-017-0562-8pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3104
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectAnemia, Hemolyticpt_PT
dc.subjectAutoantibodiespt_PT
dc.subjectAutoantigenspt_PT
dc.subjectErythema Infectiosumpt_PT
dc.subjectFemalept_PT
dc.subjectGangliosidespt_PT
dc.subjectHumanspt_PT
dc.subjectOculomotor Nerve Diseasespt_PT
dc.subjectOptic Nerve Diseasespt_PT
dc.subjectPolyneuropathiespt_PT
dc.subjectYoung Adultpt_PT
dc.subjectCHLC NEUpt_PT
dc.titleParvovirus B19 Infection Associated with Hemolytic Anemia and Cranial Polyneuropathypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage788pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage786pt_PT
oaire.citation.titleJournal of Neurovirologypt_PT
oaire.citation.volume23pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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