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Dermoscopic and Reflectance Confocal Microscopic Presentation of Hailey‐Hailey Disease: a Case Series

2017-02Journal article Open access
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dc.contributor.authorOliveira, A
dc.contributor.authorArzberger, E
dc.contributor.authorPimentel, B
dc.contributor.authorSousa, V
dc.contributor.authorLeal‐Filipe, P
dc.date.accessioned2023-10-09T14:22:02Z
dc.date.available2023-10-09T14:22:02Z
dc.date.issued2017-02
dc.description.abstractBackground/purpose: Hailey-Hailey disease is a rare inherited acantholytic skin disorder characterized by heterogeneous clinical presentation. Its differential diagnosis might be wide, including other genodermatoses, inflammatory, and infectious skin diseases. Although histopathology remains as diagnostic gold standard, noninvasive techniques such as dermoscopy and reflectance confocal microscopy may assist clinical examination. Herein, we aim to further characterize the dermoscopic and reflectance confocal microscopic presentation of Hailey-Hailey disease with histologic correlation. Methods: Eight patients with Hailey-Hailey disease were consecutively recruited. All patients were examined using dermoscopy and reflectance confocal microscopy. Results: In all cases, dermoscopy enabled the visualization of polymorphous vessels, including glomerular and linear-looped vessels, within a pink-whitish background. Reflectance confocal microscopy revealed wide suprabasilar partial acantholysis and clefting, crusts, dilated papillae with tortuous vessels, and inflammatory cells. Dyskeratosis, uplocated papillae, and adnexal sparing were also observed. Conclusion: Although definite diagnosis was obtained by histopathology in all cases, dermoscopy and reflectance confocal microscopy allowed the identification of common features (even in cases with dissimilar clinical presentation) that may support an early diagnosis of Hailey-Hailey disease, and its differentiation from other more frequent skin disorders.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSkin Res Technol . 2018 Feb;24(1):85-92.pt_PT
dc.identifier.doi10.1111/srt.12394pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4714
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectHSAC DERpt_PT
dc.subjectHumanspt_PT
dc.subjectAdultpt_PT
dc.subjectMalept_PT
dc.subjectFemalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectDermoscopy / methodspt_PT
dc.subjectDiagnosis, Differentialpt_PT
dc.subjectMicroscopy, Confocal / methodspt_PT
dc.subjectPemphigus, Benign Familial / diagnosis*pt_PT
dc.subjectPemphigus, Benign Familial / pathologypt_PT
dc.titleDermoscopic and Reflectance Confocal Microscopic Presentation of Hailey‐Hailey Disease: a Case Seriespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage92pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage85pt_PT
oaire.citation.titleSkin Research and Technologypt_PT
oaire.citation.volume24pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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