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Impact of Age and Sex on Left Ventricular Function Determined by Coronary Computed Tomographic Angiography: Results From the Prospective Multicentre CONFIRM Study

2017-09-01Journal article Open access
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dc.contributor.authorGebhard, C
dc.contributor.authorBuechel, RR
dc.contributor.authorStähli, BE
dc.contributor.authorGransar, H
dc.contributor.authorAchenbach, S
dc.contributor.authorBerman, DS
dc.contributor.authorBudoff, MJ
dc.contributor.authorCallister, TQ
dc.contributor.authorChow, B
dc.contributor.authorDunning, A
dc.contributor.authorAl-Mallah, MH
dc.contributor.authorCademartiri, F
dc.contributor.authorChinnaiyan, K
dc.contributor.authorRubinshtein, R
dc.contributor.authorPinto Marques, H
dc.contributor.authorDeLago, A
dc.contributor.authorVillines, TC
dc.contributor.authorHadamitzky, M
dc.contributor.authorHausleiter, J
dc.contributor.authorShaw, LJ
dc.contributor.authorCury, RC
dc.contributor.authorFeuchtner, G
dc.contributor.authorKim, YJ
dc.contributor.authorMaffei, E
dc.contributor.authorRaff, G
dc.contributor.authorPontone, G
dc.contributor.authorAndreini, D
dc.contributor.authorChang, HJ
dc.contributor.authorLeipsic, J
dc.contributor.authorMin, JK
dc.contributor.authorKaufmann, PA
dc.date.accessioned2019-03-12T16:10:07Z
dc.date.available2019-03-12T16:10:07Z
dc.date.issued2017-09-01
dc.description.abstractBACKGROUND: Left ventricular (LV) volumetric and functional parameters measured with cardiac computed tomography (cardiac CT) augment risk prediction and discrimination for future mortality. Gender- and age-specific standard values for LV dimensions and systolic function obtained by 64-slice cardiac CT are lacking. METHODS AND RESULTS: 1155 patients from the Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry (54.5% males, mean age 53.1 ± 12.4 years, range: 18-92 years) without known coronary artery disease (CAD), structural heart disease, diabetes, or hypertension who underwent cardiac CT for various indications were categorized according to age and sex. A cardiac CT data acquisition protocol was used that allowed volumetric measuring of LV function. Image interpretation was performed at each site. Patients with significant CAD (>50% stenosis) on cardiac CT were excluded from the analysis. Overall, mean left ventricular ejection fraction (LVEF) was higher in women when compared with men (66.6 ± 7.7% vs. 64.6 ± 8.1%, P < 0.001). This gender-difference in overall LVEF was caused by a significantly higher LVEF in women ≥70 years when compared with men ≥70 years (69.95 ± 8.89% vs. 65.50 ± 9.42%, P = 0.004). Accordingly, a significant increase in LVEF was observed with age (P = 0.005 for males and P < 0.001 for females), which was more pronounced in females (5.21%) than in males (2.6%). LV end-diastolic volume decreased in females from 122.48 ± 27.87 (<40 years) to 95.56 ± 23.17 (>70 years; P < 0.001) and in males from 155.22 ± 35.07 (<40 years) to 130.26 ± 27.18 (>70 years; P < 0.001). CONCLUSION: Our findings indicate that the LV undergoes a lifelong remodelling and highlight the need for age and gender adjusted reference values.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur Heart J Cardiovasc Imaging. 2017 Sep 1;18(9):990-1000.pt_PT
dc.identifier.doi10.1093/ehjci/jew142pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3180
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEuropean Society of Cardiologypt_PT
dc.subjectAdultpt_PT
dc.subjectAge Factorspt_PT
dc.subjectAgedpt_PT
dc.subjectAnalysis of Variancept_PT
dc.subjectCohort Studiespt_PT
dc.subjectComputed Tomography Angiographypt_PT
dc.subjectCoronary Angiographypt_PT
dc.subjectCoronary Artery Diseasept_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPrognosispt_PT
dc.subjectProspective Studiespt_PT
dc.subjectRegistriespt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectSeverity of Illness Indexpt_PT
dc.subjectSex Factorspt_PT
dc.subjectStatistics, Nonparametricpt_PT
dc.subjectSurvival Ratept_PT
dc.subjectVentricular Dysfunction, Leftpt_PT
dc.subjectHCC CIRpt_PT
dc.titleImpact of Age and Sex on Left Ventricular Function Determined by Coronary Computed Tomographic Angiography: Results From the Prospective Multicentre CONFIRM Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1000pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage990pt_PT
oaire.citation.titleEHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imagingpt_PT
oaire.citation.volume18pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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