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Prognostic Power of Anaerobic Threshold Parameters in Patients with Transposition of the Great Arteries and Systemic Right Ventricle

2019-12Journal article Open access
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dc.contributor.authorValentim Gonçalves, A
dc.contributor.authorMano, T
dc.contributor.authorAgapito, A
dc.contributor.authorAguiar Rosa, S
dc.contributor.authorSousa, L
dc.contributor.authorRio, P
dc.contributor.authorOliveira, JA
dc.contributor.authorMonteiro, A
dc.contributor.authorPereira-da-Silva, T
dc.contributor.authorIlhão Moreira, R
dc.contributor.authorSoares, R
dc.contributor.authorPinto, MF
dc.contributor.authorCruz Ferreira, R
dc.date.accessioned2020-02-06T16:36:07Z
dc.date.available2020-02-06T16:36:07Z
dc.date.issued2019-12
dc.description.abstractINTRODUCTION: Both transposition of the great arteries (TGA) previously submitted to a Senning/Mustard procedure and congenitally corrected TGA (cc-TGA) have the systemic circulation supported by the morphological right ventricle, thereby rendering these patients to heart failure events risk. The aim of this study was to evaluate cardiopulmonary exercise test parameters for stratifying the risk of heart failure events in TGA patients. METHODS: Retrospective evaluation of adult TGA patients with systemic circulation supported by the morphological right ventricle submitted to cardiopulmonary exercise test in a tertiary centre. Patients were followed up for at least 1 year for the primary endpoint of cardiac death or heart failure hospitalisation. Several cardiopulmonary exercise test parameters were analysed as potential predictors of the combined endpoint and their predictive power were compared (area under the curve). RESULTS: Cardiopulmonary exercise test was performed in 44 TGA patients (8 cc-TGA), with a mean age of 35.1 ± 8.4 years. The primary endpoint was reached by 10 (22.7%) patients, with a mean follow-up of 36.7 ± 26.8 months. Heart rate at anaerobic threshold had the highest area under the curve value (0.864), followed by peak oxygen consumption (pVO2) (0.838). Heart rate at anaerobic threshold ≤95 bpm and pVO2 ≤20 ml/kg/min had a sensitivity of 87.5 and 80.0% and a specificity of 82.4 and 76.5%, respectively, for the primary outcome. CONCLUSION: Heart rate at anaerobic threshold ≤95 bpm had the highest predictive power of all cardiopulmonary exercise test parameters analysed for heart failure events in TGA patients with systemic circulation supported by the morphological right ventricle.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCardiol Young. 2019 Dec;29(12):1445-1451.pt_PT
dc.identifier.doi10.1017/S1047951119002361pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3424
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCambridge University Presspt_PT
dc.subjectHSM CARpt_PT
dc.subjectAdultpt_PT
dc.subjectFemalept_PT
dc.subjectMalept_PT
dc.subjectHumanspt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectYoung Adult
dc.subjectAnaerobic Threshold / physiology
dc.subjectExercise Test / methods
dc.subjectHeart Failure / mortality
dc.subjectHeart Failure / physiopathology
dc.subjectPortugal / epidemiology
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectTertiary Care Centers
dc.subjectRisk Assessment / methods
dc.subjectTransposition of Great Vessels / physiopathology
dc.subjectVentricular Dysfunction, Right / physiopathology
dc.titlePrognostic Power of Anaerobic Threshold Parameters in Patients with Transposition of the Great Arteries and Systemic Right Ventriclept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1451pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1445pt_PT
oaire.citation.titleCardiology in the Youngpt_PT
oaire.citation.volume29pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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