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Implementing an Influenza Vaccine Effectiveness Study in a Hospital Context in Portugal: The EVA Hospital Project

2021-01Journal article Open access
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dc.contributor.authorMachado, A
dc.contributor.authorGomez, V
dc.contributor.authorPanarra, A
dc.contributor.authorPoças, J
dc.contributor.authorCorte-Real, R
dc.contributor.authorPeres, MJ
dc.contributor.authorNunes, B
dc.date.accessioned2021-02-03T16:19:37Z
dc.date.available2021-02-03T16:19:37Z
dc.date.issued2021-01
dc.description.abstractIntroduction: The project ‘Integrated Monitoring of Vaccines in Europe’ aimed to measure seasonal influenza vaccine effectiveness against hospitalised adults, aged 65 years and over, with influenza. We describe the protocol implementation in Portugal. Material and Methods: We implemented a test-negative design, targeting community-dwelling patients aged 65 years old and over hospitalised with severe acute respiratory illness. Patients were reverse transverse-polymerase chain reaction tested for influenza. Cases were those positive for influenza while others were controls. Most variables were collected using hospital medical records. Selection bias was evaluated by comparison with the laboratory influenza test requests database according to demographic characteristics. Crude, season-adjusted influenza vaccine effectiveness was estimated as = 1 – odds ratio, and 95% confidence intervals were obtained by conditional logistical regression, matched with the disease onset month. Results: The recruitment rate was 37.8%. Most participants (n = 368) were female (55.8%) and aged 80 years old and over (55.8%). This was similar to values for potentially eligible severe acute respiratory illness patients (80 years old and over: 56.8%, female: 56.2%). The proportion of missing values was below 2.5% for 20 variables and above 5% (maximum 11.6%) for six variables. Influenza vaccine effectiveness estimates were 62.1% against AH1pdm09 (95% confidence intervals: -28.1 to 88.8), 14.9% against A(H3N2) (95% confidence intervals: -69.6 to 57.3), 43.6% against B/Yam (95% confidence intervals: -66.2 to 80.8). Discussion: Given the non-existence of a coded admission database in either participating hospital the selection of severe acute respiratory illness due to clinical features was the feasible one. These results are only valid for the older adult population residing in the catchment area of the two participating hospitals who were admitted to a public hospital with severe influenza or SARI symptoms. Conclusion: Despite the low participation rate, we observed comparable characteristics of participants and eligible severe acute respiratory illness patients. Data quality was high, and influenza vaccine effectiveness results were in accordance with the results of meta-analyses and European season-specific estimates. The final sample size was low, which inhibited obtaining estimates with good precision.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Med Port 2021 Jan;34(1):20-27pt_PT
dc.identifier.doi10.20344/amp.13438pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3557
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOrdem dos Médicospt_PT
dc.subjectHCC MEDpt_PT
dc.subjectHCC PAT CLINpt_PT
dc.subjectInfluenza, Humanpt_PT
dc.subjectInfluenza Vaccinespt_PT
dc.subjectPortugalpt_PT
dc.subjectRespiratory Tract Infectionspt_PT
dc.subjectReverse Transcriptase Polymerase Chain Reactionpt_PT
dc.titleImplementing an Influenza Vaccine Effectiveness Study in a Hospital Context in Portugal: The EVA Hospital Projectpt_PT
dc.title.alternativeImplementação de um Estudo de Efetividade da Vacina Contra a Gripe no Contexto Hospitalar em Portugal: Projeto EVA Hospitalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage27pt_PT
oaire.citation.issue13pt_PT
oaire.citation.startPage20pt_PT
oaire.citation.titleActa Médica Portuguesapt_PT
oaire.citation.volume33pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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