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Three-Dimensional Speckle-Tracking Echocardiography for the Global and Regional Assessments of Left Ventricle Myocardial Deformation in Breast Cancer Patients Treated with Anthracyclines

2020-06Journal article Open access
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dc.contributor.authorCoutinho Cruz, M
dc.contributor.authorBranco, LM
dc.contributor.authorPortugal, G
dc.contributor.authorGalrinho, A
dc.contributor.authorTimóteo, AT
dc.contributor.authorRio, P
dc.contributor.authorIlhão Moreira, R
dc.contributor.authorMendonça, T
dc.contributor.authorLeal, A
dc.contributor.authorGameiro, F
dc.contributor.authorDuarte Oliveira, S
dc.contributor.authorLuz, R
dc.contributor.authorCruz Ferreira, R
dc.date.accessioned2021-02-19T17:27:11Z
dc.date.available2021-02-19T17:27:11Z
dc.date.issued2020-06
dc.description.abstractBackground: Assessment of 2D/3D left ventricular ejection fraction (LVEF) and 2D global longitudinal strain (GLS) is the gold standard for diagnosing cancer therapeutics-related cardiac dysfunction (CTRCD). Although 3D speckle-tracking echocardiography (STE) has several advantages, it is not used in this setting. Methods: 105 breast cancer patients who underwent serial echocardiographic assessment during anthracycline therapy were included. STE was used to estimate 2D GLS, 3D GLS, 3D global circumferential strain (GCS), 3D global radial strain (GRS), and 3D global area strain (GAS). CTRCD was defined as an absolute decrease in 2D/3D LVEF > 10% to a value < 54% or a relative decrease in 2D GLS > 15%. Results: 24 patients developed CTRCD. There was a significant worsening of all 3D strain parameters during chemotherapy. 3D strain regional analysis showed impaired contractility in the anterior, inferior, and septal walls. Variations of 3D GRS and 3D GCS were associated with a higher incidence of CTRCD and the variation of 3D GRS was an independent predictor of CTRCD. Variations of 3D GCS and 3D GRS had a good discrimination for predicting CTRCD, with optimal cutoff values of - 34.2% for 3D GCS and - 34.4% for 3D GRS. These variations were observed 45 and 23 days before the diagnosis of CTRCD, respectively. Conclusion: Variations of 3D strain parameters were predictive of and preceded CTRCD, and thus have added value over currently recommended 2D/3D LVEF and 2D GLS. Routine application of this technique should be considered to offer targeted monitoring and timely initiation of cardioprotective treatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Res Cardiol. 2020 Jun;109(6):673-684.pt_PT
dc.identifier.doi10.1007/s00392-019-01556-1pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3574
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerLinkpt_PT
dc.subjectHSM CARpt_PT
dc.subjectHSAC ONCpt_PT
dc.subjectAnthracyclines /adverse effectspt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectBreast Neoplasms/drug therapypt_PT
dc.subjectEchocardiography, Three-Dimensional/methodspt_PT
dc.subjectCardiotoxicity
dc.subjectFollow-Up Studies
dc.subjectHeart Ventricles/diagnostic imaging
dc.subjectHeart Ventricles/ physiopathology
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectPrognosis
dc.subjectStroke Volume/drug effects
dc.subjectProspective Studies
dc.subjectStroke Volume/physiology
dc.subjectStroke Volume/drug effects
dc.subjectVentricular Dysfunction, Left/chemically induced
dc.subjectVentricular Dysfunction, Left/diagnosis
dc.subjectVentricular Dysfunction, Left/physiopathology
dc.subjectVentricular Function, Left/drug effects
dc.subjectVentricular Function, Left/physiology
dc.titleThree-Dimensional Speckle-Tracking Echocardiography for the Global and Regional Assessments of Left Ventricle Myocardial Deformation in Breast Cancer Patients Treated with Anthracyclinespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage684pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage673pt_PT
oaire.citation.titleClinical Research in Cardiologypt_PT
oaire.citation.volume109pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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