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Rare Diagnosis in a Patient with Diabetes with Nephrotic Proteinuria

2019Journal article Open access
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dc.contributor.authorAzevedo, A
dc.contributor.authorCotovio, P
dc.contributor.authorGóis, M
dc.contributor.authorNolasco, F
dc.date.accessioned2022-05-03T14:55:40Z
dc.date.available2022-05-03T14:55:40Z
dc.date.issued2019
dc.description.abstractWe report a 63-year-old man with well-controlled type 2 diabetes mellitus and hypertension, who presented with new onset nephrotic proteinuria and rapid deterioration in renal function. The atypical clinical presentation prompted us to consider a non-diabetic and non-hypertensive cause and to perform a renal biopsy. A diagnosis of fibrillarglomerulonephritis (FGn) was made based on electronic microscopy. Proteinuria remained in nephrotic range despite treatment with prednisolone, and renal function deteriorated. We suggest that other causes of proteinuria should be considered in patients with diabetes who present with the nephrotic syndrome when there is no other evidence of microvascular disease. We review the spectrum of fibrillar glomerulopathies including FGn, primary and secondary amyloidosis and immunotactoid glomerulonephritis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMJ Case Rep. 2019 Jan 10;12(1):bcr-2017-223835.pt_PT
dc.identifier.doi10.1136/bcr-2017-223835.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4064
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJpt_PT
dc.subjectHCC NEFpt_PT
dc.subjectMalept_PT
dc.subjectHumanspt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectAmyloidosis / diagnosispt_PT
dc.subjectBiopsy / methodspt_PT
dc.subjectDiabetes Mellitus, Type 2 / complicationspt_PT
dc.subjectDiabetes Mellitus, Type 2 / epidemiologypt_PT
dc.subjectGlomerulonephritis / pathology*pt_PT
dc.subjectGlucocorticoids / therapeutic usept_PT
dc.subjectNephrotic Syndrome / diagnosis*pt_PT
dc.subjectNephrotic Syndrome / etiologypt_PT
dc.subjectNephrotic Syndrome / pathologypt_PT
dc.subjectPrednisolone / administration & dosagept_PT
dc.subjectPrednisolone / therapeutic usept_PT
dc.subjectProteinuria / diagnosis*pt_PT
dc.subjectProteinuria / etiologypt_PT
dc.subjectRare Diseasespt_PT
dc.subjectTreatment Outcomept_PT
dc.subjectVascular Access Devices / standardspt_PT
dc.titleRare Diagnosis in a Patient with Diabetes with Nephrotic Proteinuriapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleBMJ Case Reportspt_PT
oaire.citation.volume12pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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