Repository logo
 
Publication

Hepatocellular Carcinoma Tumour Burden Score to Stratify Prognosis After Resection

2020-06Journal article Open access
Simple item page
dc.contributor.authorTsilimigras, D
dc.contributor.authorMoris, D
dc.contributor.authorHyer, J
dc.contributor.authorBagante, F
dc.contributor.authorSahara, K
dc.contributor.authorMoro, A
dc.contributor.authorParedes, A
dc.contributor.authorMehta, R
dc.contributor.authorRatti, F
dc.contributor.authorPinto Marques, H
dc.contributor.authorSilva, S
dc.contributor.authorSoubrane, O
dc.contributor.authorLam, V
dc.contributor.authorPoultsides, G
dc.contributor.authorPopescu, I
dc.contributor.authorAlexandrescu, S
dc.contributor.authorMartel, G
dc.contributor.authorWorkneh, A
dc.contributor.authorGuglielmi, A
dc.contributor.authorHugh, T
dc.contributor.authorAldrighetti, L
dc.contributor.authorEndo, I
dc.contributor.authorSasaki, K
dc.contributor.authorRodarte, A
dc.contributor.authorAucejo, F
dc.contributor.authorPawlik, T
dc.date.accessioned2023-03-15T15:56:33Z
dc.date.available2023-03-15T15:56:33Z
dc.date.issued2020-06
dc.description.abstractBackground: Although the Barcelona Clinic Liver Cancer (BCLC) staging system has been largely adopted in clinical practice, recent studies have emphasized the need for further refinement and subclassification of this system. Methods: Patients who underwent hepatectomy with curative intent for BCLC-0, -A or -B hepatocellular carcinoma (HCC) between 2000 and 2017 were identified using a multi-institutional database. The tumour burden score (TBS) was calculated, and overall survival (OS) was examined in relation to TBS and BCLC stage. Results: Among 1053 patients, 63 (6·0 per cent) had BCLC-0, 826 (78·4 per cent) BCLC-A and 164 (15·6 per cent) had BCLC-B HCC. OS worsened incrementally with higher TBS (5-year OS 77·9, 61 and 39 per cent for low, medium and high TBS respectively; P < 0·001). No differences in OS were noted among patients with similar TBS, irrespective of BCLC stage (61·6 versus 58·9 per cent for BCLC-A/medium TBS versus BCLC-B/medium TBS, P = 0·930; 45 versus 13 per cent for BCLC-A/high TBS versus BCLC-B/high TBS, P = 0·175). Patients with BCLC-B HCC and a medium TBS had better OS than those with BCLC-A disease and a high TBS (58·9 versus 45 per cent; P = 0·005). On multivariable analysis, TBS remained associated with OS among patients with BCLC-A (medium TBS: hazard ratio (HR) 2·07, 95 per cent c.i. 1·42 to 3·02, P < 0·001; high TBS: HR 4·05, 2·40 to 6·82, P < 0·001) and BCLC-B (high TBS: HR 3·85, 2·03 to 7·30; P < 0·001) HCC. TBS could also stratify prognosis among patients in an external validation cohort (5-year OS 79, 51·2 and 28 per cent for low, medium and high TBS respectively; P = 0·010). Conclusion: The prognosis of patients with HCC varied according to the BCLC stage but was largely dependent on the TBS.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBr J Surg . 2020 Jun;107(7):854-864pt_PT
dc.identifier.doi10.1002/bjs.11464pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4447
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sonspt_PT
dc.subjectHCC CIRpt_PT
dc.subjectAgedpt_PT
dc.subjectFemalept_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectHumanspt_PT
dc.subjectCarcinoma, Hepatocellular / diagnosis*pt_PT
dc.subjectCarcinoma, Hepatocellular / mortalitypt_PT
dc.subjectCarcinoma, Hepatocellular / pathologypt_PT
dc.subjectCarcinoma, Hepatocellular / surgerypt_PT
dc.subjectDisease-Free Survivalpt_PT
dc.subjectKaplan-Meier Estimatept_PT
dc.subjectLiver Neoplasms / diagnosis*pt_PT
dc.subjectLiver Neoplasms / mortalitypt_PT
dc.subjectLiver Neoplasms / pathologypt_PT
dc.subjectLiver Neoplasms / surgerypt_PT
dc.subjectNeoplasm Staging / methodspt_PT
dc.subjectPrognosispt_PT
dc.subjectSurvival Analysispt_PT
dc.subjectTumor Burdenpt_PT
dc.titleHepatocellular Carcinoma Tumour Burden Score to Stratify Prognosis After Resectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage864pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage854pt_PT
oaire.citation.titleBritish Journal of Surgerypt_PT
oaire.citation.volume107pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
BJS 2020 854.pdf
Size:
407.22 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIR - Artigos