Publication
Hypophosphatemia As a Possible Biomarker for Epileptic Seizures at the Emergency Department
| dc.contributor.author | Coutinho, M | |
| dc.contributor.author | Faustino, P | |
| dc.contributor.author | Ladeira, F | |
| dc.contributor.author | Leitão, L | |
| dc.date.accessioned | 2023-10-03T14:54:05Z | |
| dc.date.available | 2023-10-03T14:54:05Z | |
| dc.date.issued | 2023-07 | |
| dc.description.abstract | Introduction: Hypophosphatemia seems to be temporally associated with seizures, despite not being considered a trigger. We aimed to evaluate hypophosphatemia as a biomarker for seizures. Methods: Retrospective study, including all consecutive patients admitted at our central hospital's emergency department from 01/01-31/03/2021, screened as "altered consciousness/syncope" or "seizures", with available phosphate levels. Results: 277 patients included, mostly male (61.7%), mean age 64.3 years. Final diagnosis was "seizure" in 34.7% and "other diagnosis" in 65.3%. Patients with seizures were younger (p<0.001), had more frequent epilepsy (p<0.001) and alcoholism (p=0.01). Patients with other diagnosis had more often renal failure (p<0.001) and statin (p=0.02) or diuretic (p=0.003) therapy. Time to blood collection (from the event and from admission) was similar between groups. Patients with seizures had lower mean phosphate levels and more frequent hypophosphatemia (<2.4mg/dL) (p<0.001). Mean CK levels were similar in both groups (p=0.25). HyperCK (>200U/L) was more frequent in the seizure group (p=0.04). Odds ratio (OR) of hypophosphatemia for seizures was 4.330 (CI 95% 2.170-8.640, p<0.001), persisting after correction for confounders. OR of hyperCK was 1.890 (CI 95% 1.060-3.371, p=0.03), losing significance when adjusted. Sensitivity was low for both. Hypophosphatemia was more specific (91.2% vs 79.9%). Conclusions: Our findings support hypophosphatemia as a seizure biomarker. More studies are needed. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Seizure . 2023 Jul 17;111:42-44. | pt_PT |
| dc.identifier.doi | 10.1016/j.seizure.2023.07.012 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/4706 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.subject | HSJ NEU | pt_PT |
| dc.subject | Creatine Kinase | pt_PT |
| dc.subject | Hypophosphatemia | pt_PT |
| dc.subject | Phosphate | pt_PT |
| dc.subject | Seizures | pt_PT |
| dc.subject | Transient Altered Level of Consciousness | pt_PT |
| dc.title | Hypophosphatemia As a Possible Biomarker for Epileptic Seizures at the Emergency Department | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 44 | pt_PT |
| oaire.citation.startPage | 42 | pt_PT |
| oaire.citation.title | Seizure: European Journal of Epilepsy | pt_PT |
| oaire.citation.volume | 111 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |