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Association Between Physical Activity and Mortality in End-Stage Kidney Disease: a Systematic Review of Observational Studies

2021Journal article Open access
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dc.contributor.authorMartins, P
dc.contributor.authorMarques, E
dc.contributor.authorLeal, D
dc.contributor.authorFerreira, A
dc.contributor.authorWilund, K
dc.contributor.authorViana, J
dc.date.accessioned2022-08-12T15:02:47Z
dc.date.available2022-08-12T15:02:47Z
dc.date.issued2021
dc.description.abstractBackground: End-stage Kidney Disease patients have a high mortality and hospitalization risk. The association of these outcomes with physical activity is described in the general population and in other chronic diseases. However, few studies examining this association have been completed in end-stage Kidney Disease patients, raising the need to systematically review the evidence on the association of physical activity with mortality and hospitalization in this population. Methods: Electronic databases (EBSCO, Scopus and Web of Science) and hand search were performed until March 2020 for observational studies reporting the association of physical activity with mortality or hospitalization in adult end-stage Kidney Disease patients on renal replacement therapy (hemodialysis, peritoneal dialysis and kidney transplant). Methodological quality of the included studies was assessed using the Quality in Prognosis Studies tool. The review protocol was registered in PROSPERO (CRD42020155591). Results: Eleven studies were included: six in hemodialysis, three in kidney transplant, and two in hemodialysis and peritoneal dialysis patients. Physical activity was self-reported, except in one study that used accelerometers. All-cause mortality was addressed in all studies and cardiovascular mortality in three studies. Nine studies reported a significant reduction in all-cause mortality with increased levels of physical activity. Evidence of a dose-response relationship was found. For cardiovascular mortality, a significant reduction was observed in two of the three studies. Only one study investigated the association of physical activity with hospitalization. Conclusions: Higher physical activity was associated with reduced mortality in end-stage Kidney Disease patients. Future studies using objective physical activity measures could strengthen these findings. The association of physical activity with hospitalization should be explored in future investigations.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMC Nephrol. 2021 Jun 18;22(1):227.pt_PT
dc.identifier.doidoi: 10.1186/s12882-021-02407-w.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4206
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.subjectHCC NEFpt_PT
dc.subjectAdultpt_PT
dc.subjectHumanspt_PT
dc.subjectPrognosispt_PT
dc.subjectCardiovascular Diseases / complicationspt_PT
dc.subjectCardiovascular Diseases / mortalitypt_PT
dc.subjectCause of Deathpt_PT
dc.subjectDisease Progressionpt_PT
dc.subjectExercisept_PT
dc.subjectHospitalizationpt_PT
dc.subjectKidney Failure, Chronic / complicationspt_PT
dc.subjectKidney Failure, Chronic / mortalitypt_PT
dc.subjectKidney Failure, Chronic / therapypt_PT
dc.subjectKidney Transplantationpt_PT
dc.subjectObservational Studies as Topicpt_PT
dc.subjectPeritoneal Dialysispt_PT
dc.subjectRenal Dialysispt_PT
dc.titleAssociation Between Physical Activity and Mortality in End-Stage Kidney Disease: a Systematic Review of Observational Studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage227pt_PT
oaire.citation.titleBMC Nephrologypt_PT
oaire.citation.volume22pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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