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Antiphospholipid Syndrome and Recurrent Thrombosis--Limitations of Current Treatment Strategies

2012-03-08Journal article Open access
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dc.contributor.authorCoelho Henriques, C
dc.contributor.authorLourenço, F
dc.contributor.authorLopéz, B
dc.contributor.authorPanarra, A
dc.contributor.authorRiso, N
dc.date.accessioned2018-05-23T10:26:34Z
dc.date.available2018-05-23T10:26:34Z
dc.date.issued2012-03-08
dc.description.abstractAntiphospholipid syndrome (APS) is a systemic autoimmune disorder that is characterised by the presence of antiphospholipid antibodies and a common cause of vascular thromboembolic phenomena. The management of patients with APS is currently directed to antithrombotic medications. The international therapeutic guidelines recommend oral anticoagulation with warfarin indefinitely after the first thrombotic episode. However, therapeutic guidelines lack for a minority group of patients - the patients appropriately anticoagulated with recurrent thromboembolic phenomena. The authors present a clinical report that reveals the therapeutic and diagnostic complexity of this specific group of patients. Regarding recent studies, APS has been revealed as a complex syndrome with multiple pathophysiological mechanisms previously unknown. In this context, new therapeutic approaches have been defended and empirically experienced, with potentially promising results.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMJ Case Rep. 2012 Mar 8;2012. pii: bcr1120115147pt_PT
dc.identifier.doi10.1136/bcr.11.2011.5147pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2983
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.subjectAntibodies, Antiphospholipidpt_PT
dc.subjectAntiphospholipid Syndromept_PT
dc.subjectBronchoscopypt_PT
dc.subjectDiagnosis, Differentialpt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPulmonary Embolismpt_PT
dc.subjectRisk Factorspt_PT
dc.subjectThrombosispt_PT
dc.subjectTomography, X-Ray Computedpt_PT
dc.subjectHCC MEDpt_PT
dc.titleAntiphospholipid Syndrome and Recurrent Thrombosis--Limitations of Current Treatment Strategiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPagebcr1120115147pt_PT
oaire.citation.issuemar08 1pt_PT
oaire.citation.startPagebcr1120115147pt_PT
oaire.citation.titleBMJ Case Reportspt_PT
oaire.citation.volume2012pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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