Publication
Non-Uremic Calciphylaxis: a Rare Diagnosis with Limited Therapeutic Strategies
| dc.contributor.author | Gomes, F | |
| dc.contributor.author | La Feria, P | |
| dc.contributor.author | Costa, C | |
| dc.contributor.author | Santos, R | |
| dc.date.accessioned | 2022-05-13T14:33:58Z | |
| dc.date.available | 2022-05-13T14:33:58Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Calciphylaxis is a rare condition characterized by the emergence of non-healing skin ulcers secondary to arterial calcification and thrombosis, typically diagnosed in patients with end-stage kidney disease (ESKD). When it develops in patients without ESKD, it is called non-uremic calciphylaxis (NUC). The latter is an even rarer diagnosis with an uncertain pathophysiology and a high mortality rate (52%), mainly due to sepsis (50%). Cutaneous biopsy is diagnostic. Therapeutic measures recommended for NUC are limited to wound debridement, analgesia, and control of infection and risk factors. Other therapeutic options exist but with a low level of evidence. We present the case of a 78-year-old woman with NUC in her lower limbs who died of sepsis. NUC is a therapeutic challenge lacking efficient strategies. Learning points: Calciphylaxis in the absence of end-stage kidney disease is called non-uremic calciphylaxis (NUC).This disease is a diagnostic and therapeutic challenge.As therapeutic strategies for NUC mainly derive from those for uremic calciphylaxis, more efficient therapeutic measures and evidence-based recommendations are needed. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Eur J Case Rep Intern Med. 2018 Dec 27;5(12):000986 | pt_PT |
| dc.identifier.doi | 10.12890/2018_000986. | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/4078 | |
| dc.language.iso | eng | pt_PT |
| dc.subject | HSAC MED | pt_PT |
| dc.subject | Leg Ulcer | pt_PT |
| dc.subject | Calciphylaxis | pt_PT |
| dc.subject | Sepsis | pt_PT |
| dc.subject | Vascular Calcification | pt_PT |
| dc.title | Non-Uremic Calciphylaxis: a Rare Diagnosis with Limited Therapeutic Strategies | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | European Journal of Case Reports in Internal Medicine | pt_PT |
| oaire.citation.volume | 5 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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