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The Effect of Preoperative Chemotherapy Treatment in Surgically Treated Intrahepatic Cholangiocarcinoma Patients-A Multi-Institutional Analysis

2017-03Journal article Open access
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dc.contributor.authorBuettner, S
dc.contributor.authorKoerkamp, BG
dc.contributor.authorEjaz, A
dc.contributor.authorBuisman, FE
dc.contributor.authorKim, Y
dc.contributor.authorMargonis, GA
dc.contributor.authorAlexandrescu, S
dc.contributor.authorPinto Marques, H
dc.contributor.authorLamelas, J
dc.contributor.authorAldrighetti, L
dc.contributor.authorGamblin, TC
dc.contributor.authorMaithel, SK
dc.contributor.authorPulitano, C
dc.contributor.authorBauer, TW
dc.contributor.authorShen, F
dc.contributor.authorPoultsides, GA
dc.contributor.authorMarsh, JW
dc.contributor.authorIJzermans, JN
dc.contributor.authorPawlik, TM
dc.date.accessioned2019-03-21T10:40:02Z
dc.date.available2019-03-21T10:40:02Z
dc.date.issued2017-03
dc.description.abstractINTRODUCTION: While preoperative chemotherapy (pCT) is utilized in many intra-abdominal cancers, the use of pCT among patients with intrahepatic cholangiocarcinoma (ICC) remains ill defined. As such, the objective of the current study was to examine the impact of pCT among patients undergoing curative-intent resection for ICC. METHODS: Patients who underwent hepatectomy for ICC were identified from a multi-institutional international cohort. The association between pCT with peri-operative and long-term clinical outcomes was assessed. RESULTS: Of the 1 057 patients who were identified and met the inclusion criteria, 62 patients (5.9%) received pCT. These patients were noticed to have more advanced disease. Median OS (pCT:46.9 months vs no pCT:37.4 months; P = 0.900) and DFS (pCT: 34.1 months vs no pCT: 29.1 months; P = 0.909) were similar between the two groups. In a subgroup analysis of propensity-score matched patients, there was longer OS (pCT:46.9 months vs no pCT:29.4 months) and DFS (pCT:34.1 months vs no pCT:14.0 months); however this did not reach statistical significance (both P > 0.05). CONCLUSION: In conclusion, pCT utilization among patients with ICC was higher among patients with more advanced disease. Short-term post-operative outcomes were not affected by pCT use and receipt of pCT resulted in equivalent OS and DFS following curative-intent resection.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Surg Oncol. 2017 Mar;115(3):312-318.pt_PT
dc.identifier.doi10.1002/jso.24524pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3208
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectAgedpt_PT
dc.subjectBile Duct Neoplasmspt_PT
dc.subjectBile Ducts, Intrahepaticpt_PT
dc.subjectCholangiocarcinomapt_PT
dc.subjectCohort Studiespt_PT
dc.subjectCombined Modality Therapypt_PT
dc.subjectFemalept_PT
dc.subjectHepatectomypt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPreoperative Carept_PT
dc.subjectHCC CIRpt_PT
dc.titleThe Effect of Preoperative Chemotherapy Treatment in Surgically Treated Intrahepatic Cholangiocarcinoma Patients-A Multi-Institutional Analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage318pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage312pt_PT
oaire.citation.titleJournal of Surgical Oncologypt_PT
oaire.citation.volume115pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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