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Hepatitis E Virus Genotype 1 Cases Imported to Portugal from India, 2016

2018-03-01Journal article Open access
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dc.contributor.authorMesquita, JR
dc.contributor.authorAlmeida-Santos, M
dc.contributor.authorFernandes, M
dc.contributor.authorMaltez, F
dc.contributor.authorLino, S
dc.contributor.authorAlves, L
dc.contributor.authorAbreu-Silva, J
dc.contributor.authorOliveira, R
dc.contributor.authorCurran, M
dc.contributor.authorNascimento, M
dc.date.accessioned2019-10-11T10:18:33Z
dc.date.available2019-10-11T10:18:33Z
dc.date.issued2018-03-01
dc.description.abstractHepatitis E in industrialized countries is mainly associated with genotype 3 hepatitis E virus (HEV) and normally causes a sporadic self-limiting disease in immunocompetent individuals. Unlike genotype 3, genotypes 1 and 2 circulate in developing countries, produce severe disease and occur in the epidemic form. Hepatitis E occurring in travellers returning from endemic areas in developing countries is not a novel epidemiological occurrence, however the vast majority of cases remain to be genetically studied. The present study describes two cases of severe acute hepatitis E that required hospitalization for 6 and 9 days in two individuals of Indian nationality that had recently migrated to Portugal to work. The retrieved HEV sequences both belonged to genotype 1 and had a high degree of nucleotide sequence identity, clustering with strains isolated in India and Nepal, in 2013 and 2014. Confirmed HEV genotypes of increased pathogenicity like genotype 1 are being introduced into otherwise naïve populations of industrialized countries such as European countries with consequences difficult to predict. As far as we know the present study is the first in Portugal to describe and genetically characterize imported cases of hepatitis E infection caused by HEV genotype 1.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAnn Hepatol. 2018 Mar 1;17(2):335-338.pt_PT
dc.identifier.doi10.5604/01.3001.0010.8667pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3319
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAdultpt_PT
dc.subjectDNA, Viralpt_PT
dc.subjectEmigrants and Immigrantspt_PT
dc.subjectEmigration and Immigrationpt_PT
dc.subjectGenotypept_PT
dc.subjectHepatitis Ept_PT
dc.subjectHepatitis E viruspt_PT
dc.subjectHumanspt_PT
dc.subjectIndiapt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPortugalpt_PT
dc.subjectSeverity of Illness Indexpt_PT
dc.subjectTreatment Outcomept_PT
dc.subjectHCC PAT CLINpt_PT
dc.subjectHCC INFpt_PT
dc.titleHepatitis E Virus Genotype 1 Cases Imported to Portugal from India, 2016pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage338pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage335pt_PT
oaire.citation.titleAnnals of hepatologypt_PT
oaire.citation.volume17pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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