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Molecular Profile of Sensitization to Dermatophagoides Pteronyssinus Dust Mite in Portugal

2022Journal article Open access
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dc.contributor.authorLimão, R
dc.contributor.authorSpínola Santos, A
dc.contributor.authorAraújo, L
dc.contributor.authorCosme, J
dc.contributor.authorInácio, F
dc.contributor.authorTomaz, E
dc.contributor.authorFerrão, A
dc.contributor.authorSantos, N
dc.contributor.authorSokolova, A
dc.contributor.authorMôrete, A
dc.contributor.authorFalcão, H
dc.contributor.authorCunha, L
dc.contributor.authorFerreira, A
dc.contributor.authorBras, A
dc.contributor.authorRibeiro, F
dc.contributor.authorLozoya, C
dc.contributor.authorLeiria-Pinto, P
dc.contributor.authorPrates, S
dc.contributor.authorPlácido, J
dc.contributor.authorCoimbra, A
dc.contributor.authorTaborda-Barata, L
dc.contributor.authorPereira Santos, MC
dc.contributor.authorPereira Barbosa, M
dc.contributor.authorPineda, F
dc.date.accessioned2024-02-27T11:16:06Z
dc.date.available2024-02-27T11:16:06Z
dc.date.issued2022
dc.description.abstractBackground and objectives: To analyze component-resolved diagnosis of sensitization to Dermatophagoides pteronyssinus (Der p) in patients with respiratory allergy and the association between diagnostic findings and clinical severity in different geographical areas. Methods: The study population comprised 217 patients (mean age, 25.85 [12.7] years; 51.16% female) selected from 13 centers in Portugal (5 from the North, n=65). All had allergic rhinitis with or without asthma and positive skin prick test results to at least 1 dust mite. Specific IgE (sIgE) to Der p, Dermatophagoides farinae, Lepidoglyphus destructor, Der p 1, Der p 2, Der p 10, and Der p 23 was determined using ImmunoCAP. The Mann-Whitney test was applied for the following comparisons: rhinitis vs rhinitis and asthma; mild vs moderate-to-severe rhinitis; North vs South. Results: The prevalence of sensitization was 98.2% for Der p, and 72.4%, 89.4%, 9.7%, and 77% for Der p 1, Der p 2, Der p 10, and Der p 23, respectively. The corresponding median sIgE levels were 8.56, 17.7, 0.01, and 3.95 kUA/L. sIgE to all allergens was higher in patients with moderate-to-severe rhinitis and rhinitis with asthma (nonsignficant). Concentrations of sIgE to Der p 2 were significantly higher in the South than in the North (P=.0496). Conclusion: The most common sensitization in Portugal was to Der p. The highest prevalence and median sIgE level were observed for Der p 2. All sIgE values for molecular components were higher in more symptomatic patients (nonsignificant). Concentrations of sIgE to Der p 2 were higher in the South, probably because of the warmer temperature and/or the larger sample size.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Investig Allergol Clin Immunol 2022; Vol. 32(1): 33-39pt_PT
dc.identifier.doi10.18176/jiaci.0533pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4818
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEsmon Publicidadpt_PT
dc.subjectAdultpt_PT
dc.subjectAllergenspt_PT
dc.subjectAntigens, Dermatophagoides*pt_PT
dc.subjectDermatophagoides pteronyssinus*pt_PT
dc.subjectDustpt_PT
dc.subjectFemalept_PT
dc.subjectImmunoglobulin Ept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectPortugal / epidemiologypt_PT
dc.subjectSkin Tests / methodspt_PT
dc.subjectHDE ALERpt_PT
dc.titleMolecular Profile of Sensitization to Dermatophagoides Pteronyssinus Dust Mite in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage39pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage33pt_PT
oaire.citation.titleJournal of Investigational Allergy and Clinical Immunologypt_PT
oaire.citation.volume32pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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