Publication
Methacholine Dose-Response Slopes from Maximal Bronchial Challenge Tests in Asthmatic Children: Methodological Aspects
| dc.contributor.author | Gamboa, T | |
| dc.contributor.author | Neuparth, N | |
| dc.contributor.author | Ribeiro da Silva, I | |
| dc.contributor.author | Rosado-Pinto, J | |
| dc.contributor.author | Rendas, AB | |
| dc.date.accessioned | 2014-03-05T16:08:10Z | |
| dc.date.available | 2014-03-05T16:08:10Z | |
| dc.date.issued | 1997 | |
| dc.description.abstract | To determine whether the slope of a maximal bronchial challenge test (in which FEV1 falls by over 50%) could be extrapolated from a standard bronchial challenge test (in which FEV1 falls up to 20%), 14 asthmatic children performed a single maximal bronchial challenge test with methacholin(dose range: 0.097–30.08 umol) by the dosimeter method. Maximal dose-response curves were included according to the following criteria: (1) at least one more dose beyond a FEV1 ù 20%; and (2) a MFEV1 ù 50%. PD20 FEV1 was calculated, and the slopes of the early part of the dose-response curve (standard dose-response slopes) and of the entire curve (maximal dose-response slopes) were calculated by two methods: the two-point slope (DRR) and the least squares method (LSS) in % FEV1 × umol−1. Maximal dose-response slopes were compared with the corresponding standard dose-response slopes by a paired Student’s t test after logarithmic transformation of the data; the goodness of fit of the LSS was also determined. Maximal dose-response slopes were significantly different (p < 0.0001) from those calculated on the early part of the curve: DRR20% (91.2 ± 2.7 FEV1% z umol−1)was 2.88 times higher than DRR50% (31.6 ± 3.4 DFEV1% z umol−1), and the LSS20% (89.1 ± 2.8% FEV1 z umol−1) was 3.10 times higher than LSS 50% (28.8 ± 1.5%FEV1 z umol−1). The goodness of fit of LSS 50% was significant in all cases, whereas LSS 20% failed to be significant in one. These results suggest that maximal dose-response slopes cannot be predicted from the data of standard bronchial challenge tests. | por |
| dc.identifier.citation | Lung. 1997; 175:243–252 | por |
| dc.identifier.uri | http://hdl.handle.net/10400.17/1698 | |
| dc.language.iso | eng | por |
| dc.publisher | Springer | por |
| dc.subject | Compostos de Metacolina | por |
| dc.subject | Asma | por |
| dc.subject | Criança | por |
| dc.subject | HDE ALER | por |
| dc.title | Methacholine Dose-Response Slopes from Maximal Bronchial Challenge Tests in Asthmatic Children: Methodological Aspects | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 252 | por |
| oaire.citation.startPage | 243 | por |
| oaire.citation.volume | 175 | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |