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Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis

2018-06-01Journal article Open access
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dc.contributor.authorFerret-Sena, V
dc.contributor.authorCapela, C
dc.contributor.authorSena, A
dc.date.accessioned2018-11-23T16:08:03Z
dc.date.available2018-11-23T16:08:03Z
dc.date.issued2018-06-01
dc.description.abstractMultiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) probably caused, in most cases, by the interaction of genetic and environmental factors. This review first summarizes some clinical, epidemiological and pathological characteristics of MS. Then, the involvement of biochemical pathways is discussed in the development and repair of the CNS lesions and the immune dysfunction in the disease. Finally, the potential roles of peroxisome proliferator-activated receptors (PPAR) in MS are discussed. It is suggested that metabolic mechanisms modulated by PPAR provide a window to integrate the systemic and neurological events underlying the pathogenesis of the disease. In conclusion, the reviewed data highlight molecular avenues of understanding MS that may open new targets for improved therapies and preventive strategies for the disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Mol Sci. 2018 Jun 1;19(6). pii: E1639.pt_PT
dc.identifier.doi10.3390/ijms19061639pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3103
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMultidisciplinary Digital Publishing Institutept_PT
dc.subjectAnimalspt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectInflammationpt_PT
dc.subjectMalept_PT
dc.subjectMultiple Sclerosispt_PT
dc.subjectPeroxisome Proliferator-Activated Receptorspt_PT
dc.subjectHSAC NEUpt_PT
dc.titleMetabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.startPage1639pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume19pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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