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Ascertainment of Silent Myocardial Infarction in Patients Undergoing Percutaneous Coronary Intervention (from the GLOBAL LEADERS Trial)

2019-12-15Journal article Open access
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dc.contributor.authorChang, CC
dc.contributor.authorSpitzer, E
dc.contributor.authorChichareon, P
dc.contributor.authorTakahashi, K
dc.contributor.authorModolo, R
dc.contributor.authorKogame, N
dc.contributor.authorTomaniak, M
dc.contributor.authorKomiyama, H
dc.contributor.authorYap, SC
dc.contributor.authorHoole, SP
dc.contributor.authorGori, T
dc.contributor.authorZaman, A
dc.contributor.authorFrey, B
dc.contributor.authorCruz Ferreira, R
dc.contributor.authorBertrand, OF
dc.contributor.authorKoh, TH
dc.contributor.authorSousa, A
dc.contributor.authorMoschovitis, A
dc.contributor.authorvan Geuns, RJ
dc.contributor.authorSteg, PG
dc.contributor.authorHamm, C
dc.contributor.authorJüni, P
dc.contributor.authorVranckx, P
dc.contributor.authorValgimigli, M
dc.contributor.authorWindecker, S
dc.contributor.authorSerruys, PW
dc.contributor.authorSoliman, O
dc.contributor.authorOnuma, Y
dc.date.accessioned2020-02-06T16:22:05Z
dc.date.available2020-02-06T16:22:05Z
dc.date.issued2019-12-15
dc.description.abstractQ-wave myocardial infarction (QWMI) comprises 2 entities. First, a clinically evident MI, which can occur spontaneously or be related to a coronary procedure. Second, silent MI which is incidentally detected on serial electrocardiographic (ECG) assessment. The prevalence of silent MI after percutaneous coronary intervention (PCI) in the drug-eluting stent era has not been fully investigated. The GLOBAL LEADERS is an all-comers multicenter trial which randomized 15,991 patients who underwent PCI to 2 antiplatelet treatment strategies. The primary end point was a composite of all-cause death or nonfatal new QWMI at 2-years follow-up. ECGs were collected at discharge, 3-month and 2-year visits, and analyzed by an independent ECG core laboratory following the Minnesota code. All new QWMI were further reviewed by a blinded independent cardiologist to identify a potential clinical correlate by reviewing clinical information. Of 15,968 participants, ECG information was complete in 14,829 (92.9%) at 2 years. A new QWMI was confirmed in 186 (1.16%) patients. Transient new Q-waves were observed in 28.5% (53 of 186) of them during the follow-up. The majority of new QWMI (78%, 146 of 186) were classified as silent MI due to the absence of a clinical correlate. Silent MI accounted for 22.1% (146 of 660) of all MI events. The prevalence of silent MI did not differ significantly between treatment strategies (experimental vs reference: 0.88% vs 0.98%, p = 0.5027). In conclusion, we document the prevalence of silent MI in an all-comers population undergoing PCI in this large-scale randomized trial.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAm J Cardiol. 2019 Dec 15;124(12):1833-1840.pt_PT
dc.identifier.doi10.1016/j.amjcard.2019.08.049pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3423
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectHSM CARpt_PT
dc.subjectAgedpt_PT
dc.subjectAnalysis of Variancept_PT
dc.subjectAspirin / therapeutic usept_PT
dc.subjectAsymptomatic Diseases / mortality*
dc.subjectCoronary Angiography / methods
dc.subjectDrug Therapy, Combination
dc.subjectDrug-Eluting Stents
dc.subjectElectrocardiography / methods
dc.subjectFemale
dc.subjectHumans
dc.subjectInternationality
dc.subjectKaplan-Meier Estimate
dc.subjectMyocardial Infarction / diagnostic imaging
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMyocardial Infarction / mortality*
dc.subjectMyocardial Infarction / therapy*
dc.subjectPercutaneous Coronary Intervention / methods*
dc.subjectPercutaneous Coronary Intervention / mortality
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectRisk Assessment
dc.subjectStatistics, Nonparametric
dc.subjectSurvival Analysis
dc.subjectTicagrelor / therapeutic use*
dc.subjectTreatment Outcome
dc.titleAscertainment of Silent Myocardial Infarction in Patients Undergoing Percutaneous Coronary Intervention (from the GLOBAL LEADERS Trial)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1840pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1833pt_PT
oaire.citation.titleAmerican Journal of Cardiologypt_PT
oaire.citation.volume124pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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