Repository logo
 
Publication

Simultaneous Supratentorial and Infratentorial Pilocytic Astrocytomas in an Adult Patient with Concurrent Neurofibromatosis Type 1 and HIV Infection

dc.contributor.authorForte, D
dc.contributor.authorNabais, A
dc.contributor.authorPontinha, C
dc.contributor.authorMafra, M
dc.contributor.authorMateus, L
dc.date.accessioned2019-12-10T16:02:02Z
dc.date.available2019-12-10T16:02:02Z
dc.date.issued2018-09
dc.description.abstractBACKGROUND: Neurofibromatosis type 1 (NF1) has been identified as a predisposing factor in the development of pilocytic astrocytoma (PA), a common benign central nervous system tumor. Although this is a common association, simultaneous development of multiple lesions is an infrequent finding, especially in nonoptic and hypothalamic locations. CASE DESCRIPTION: A 41-year-old female patient with NF1 and uncontrolled human immunodeficiency virus (HIV) type 1 infection presented with a first generalized seizure and associated headache and ataxia. Imaging studies revealed 2 large intra-axial PAs, nodular-cystic in the supratentorial compartment and solid in the infratentorial compartment. Both lesions were treated by gross total resection in 2 surgeries performed 1 week apart. Despite their different imaging patterns, the tumors were histologically and genetically identical. CONCLUSIONS: We present a unique case involving 2 histologically and genetically identical PAs occurring simultaneously in supratentorial and infratentorial locations. We suggest that an intrinsic predisposition to tumor development in patients with NF1 might have been enhanced by the HIV-related immunosuppression in this case. Strict oncologic surveillance is essential in patients with a tumor predisposition syndrome combined with immunosuppression.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationWorld Neurosurg. 2018 Sep;117:172-177.pt_PT
dc.identifier.doi10.1016/j.wneu.2018.06.011pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3388
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAdultpt_PT
dc.subjectAstrocytomapt_PT
dc.subjectBrainpt_PT
dc.subjectFemalept_PT
dc.subjectHIV Infectionspt_PT
dc.subjectHIV-1pt_PT
dc.subjectHumanspt_PT
dc.subjectInfratentorial Neoplasmspt_PT
dc.subjectNeoplasms, Multiple Primarypt_PT
dc.subjectNeurofibromatosis 1pt_PT
dc.subjectSupratentorial Neoplasmspt_PT
dc.subjectCHLC NCIRpt_PT
dc.subjectCHLC PAT CLINpt_PT
dc.titleSimultaneous Supratentorial and Infratentorial Pilocytic Astrocytomas in an Adult Patient with Concurrent Neurofibromatosis Type 1 and HIV Infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage177pt_PT
oaire.citation.startPage172pt_PT
oaire.citation.titleWorld Neurosurgerypt_PT
oaire.citation.volume117pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
World Neurosurg 2018.pdf
Size:
1.58 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: