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Remote or Extraischemic Intracerebral Hemorrhage--an Uncommon Complication of Stroke Thrombolysis: Results from the Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register

2014Journal article Open access
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dc.contributor.authorMazya, M
dc.contributor.authorAhmed, N
dc.contributor.authorFord, G
dc.contributor.authorHobohm, C
dc.contributor.authorMikulik, R
dc.contributor.authorPaiva Nunes, A
dc.contributor.authorWahlgren, N
dc.date.accessioned2021-10-12T14:54:53Z
dc.date.available2021-10-12T14:54:53Z
dc.date.issued2014
dc.description.abstractBackground and purpose: Intracerebral hemorrhage after treatment with intravenous recombinant tissue-type plasminogen activator for ischemic stroke can occur in local relation to the infarct, as well as in brain areas remote from infarcted tissue. We aimed to describe risk factors, 3-month mortality, and functional outcome in patients with the poorly understood complication of remote intracerebral hemorrhage, as well as local intracerebral hemorrhage. Methods: In this study, 43 494 patients treated with intravenous recombinant tissue-type plasminogen activator, with complete imaging data, were enrolled in the Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register (SITS-ISTR) during 2002 to 2011. Baseline data were compared among 970 patients (2.2%) with remote parenchymal hemorrhage (PHr), 2325 (5.3%) with PH, 438 (1.0%) with both PH and PHr, and 39 761 (91.4%) without PH or PHr. Independent risk factors for all hemorrhage types were obtained by multivariate logistic regression. Results: Previous stroke (P=0.023) and higher age (P<0.001) were independently associated with PHr, but not with PH. Atrial fibrillation, computed tomographic hyperdense cerebral artery sign, and elevated blood glucose were associated with PH, but not with PHr. Female sex had a stronger association with PHr than with PH. Functional independence at 3 months was more common in PHr than in PH (34% versus 24%; P<0.001), whereas 3-month mortality was lower (34% versus 39%; P<0.001). Conclusions: Differences between risk factor profiles indicate an influence of previous vascular pathology in PHr and acute large-vessel occlusion in PH. Additional research is needed on the effect of pre-existing cerebrovascular disease on complications of recanalization therapy in acute ischemic stroke.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationStroke. 2014 Jun;45(6):1657-63.pt_PT
dc.identifier.doi10.1161/STROKEAHA.114.004923.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3874
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Heart Associationpt_PT
dc.subjectHSJ NEUpt_PT
dc.subjectAge Factorspt_PT
dc.subjectAgedpt_PT
dc.subjectBrain Ischemia* / chemically inducedpt_PT
dc.subjectBrain Ischemia* / diagnostic imagingpt_PT
dc.subjectBrain Ischemia* / mortalitypt_PT
dc.subjectCerebral Hemorrhage* / chemically inducedpt_PT
dc.subjectFemalept_PT
dc.subjectMalept_PT
dc.subjectCerebral Hemorrhage* / diagnostic imagingpt_PT
dc.subjectHumanspt_PT
dc.subjectCerebral Hemorrhage* / mortalitypt_PT
dc.subjectFibrinolytic Agents / adverse effects*pt_PT
dc.subjectFibrinolytic Agents / therapeutic usept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectRadiographypt_PT
dc.subjectRecombinant Proteins / adverse effectspt_PT
dc.subjectRecombinant Proteins / therapeutic usept_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectStroke* / diagnostic imagingpt_PT
dc.subjectStroke* / drug therapypt_PT
dc.subjectThrombolytic Therapy / adverse effects*pt_PT
dc.subjectTissue Plasminogen Activator / adverse effects*pt_PT
dc.subjectTissue Plasminogen Activator / therapeutic usept_PT
dc.titleRemote or Extraischemic Intracerebral Hemorrhage--an Uncommon Complication of Stroke Thrombolysis: Results from the Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Registerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1663pt_PT
oaire.citation.startPage1657pt_PT
oaire.citation.titleStrokept_PT
oaire.citation.volume45pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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