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Impact of COVID-19 Infection on Lung Function and Nutritional Status Amongst Individuals with Cystic Fibrosis: A Global Cohort Study.

2024-09Text Open access
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dc.contributor.authorSemenchuk, Julie
dc.contributor.authorNaito, Yumi
dc.contributor.authorCharman, Susan C
dc.contributor.authorCarr, Siobhán B
dc.contributor.authorCheng, Stephanie Y
dc.contributor.authorMarshall, Bruce C
dc.contributor.authorFaro, Albert
dc.contributor.authorElbert, Alexander
dc.contributor.authorGutierrez, Hector H
dc.contributor.authorGoss, Christopher H
dc.contributor.authorKaradag, Bulent
dc.contributor.authorBurgel, Pierre-Régis
dc.contributor.authorColombo, Carla
dc.contributor.authorSalvatore, Marco
dc.contributor.authorPadoan, Rita
dc.contributor.authorDaneau, Géraldine
dc.contributor.authorHarutyunyan, Satenik
dc.contributor.authorKashirskaya, Nataliya
dc.contributor.authorKirwan, Laura
dc.contributor.authorMiddleton, Peter G
dc.contributor.authorRuseckaite, Rasa
dc.contributor.authorde Monestrol, Isabelle
dc.contributor.authorNaehrlich, Lutz
dc.contributor.authorMondejar-Lopez, Pedro
dc.contributor.authorJung, Andreas
dc.contributor.authorvan Rens, Jacqui
dc.contributor.authorBakkeheim, Egil
dc.contributor.authorOrenti, Annalisa
dc.contributor.authorZomer-van Ommen, Domenique
dc.contributor.authorda Silva-Filho, Luiz Vicente Rf
dc.contributor.authorFernandes, Flavia Fonseca
dc.contributor.authorZampoli, Marco
dc.contributor.authorStephenson, Anne L
dc.date.accessioned2025-09-04T15:25:22Z
dc.date.available2025-09-04T15:25:22Z
dc.date.issued2024-09
dc.description.abstractBackground: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF). Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV1) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV1 and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection. Results: A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV1 pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection. Conclusions: No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.eng
dc.identifier.citationJ Cyst Fibros . 2024 Sep;23(5):815-822
dc.identifier.doi10.1016/j.jcf.2024.07.019
dc.identifier.other39191560
dc.identifier.urihttp://hdl.handle.net/10400.17/5171
dc.language.isoen
dc.peerreviewedyes
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectCOVID-19
dc.subjectCoronavirus
dc.subjectCystic fibrosis
dc.subjectHDE PED
dc.titleImpact of COVID-19 Infection on Lung Function and Nutritional Status Amongst Individuals with Cystic Fibrosis: A Global Cohort Study.eng
dc.typetext
dspace.entity.typePublication
oaire.citation.endPage822
oaire.citation.issue5
oaire.citation.startPage815
oaire.citation.volume23
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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