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The Role of Liver-Directed Surgery in Patients With Hepatic Metastasis From Primary Breast Cancer: a Multi-Institutional Analysis

2016Journal article Open access
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dc.contributor.authorMargonis, GA
dc.contributor.authorBuettner, S
dc.contributor.authorSasaki, K
dc.contributor.authorKim, Y
dc.contributor.authorRatti, F
dc.contributor.authorRussolillo, N
dc.contributor.authorFerrero, A
dc.contributor.authorBerger, N
dc.contributor.authorGamblin, TC
dc.contributor.authorPoultsides, G
dc.contributor.authorTran, T
dc.contributor.authorPostlewait, LM
dc.contributor.authorMaithel, S
dc.contributor.authorMichaels, AD
dc.contributor.authorBauer, TW
dc.contributor.authorPinto Marques, H
dc.contributor.authorBarroso, E
dc.contributor.authorAldrighetti, L
dc.contributor.authorPawlik, TM
dc.date.accessioned2018-07-12T15:13:17Z
dc.date.available2018-07-12T15:13:17Z
dc.date.issued2016
dc.description.abstractBACKGROUND: Data on surgical management of breast liver metastasis are limited. We sought to determine the safety and long-term outcome of patients undergoing hepatic resection of breast cancer liver metastases (BCLM). METHODS: Using a multi-institutional, international database, 131 patients who underwent surgery for BCLM between 1980 and 2014 were identified. Clinicopathologic and outcome data were collected and analyzed. RESULTS: Median tumor size of the primary breast cancer was 2.5 cm (IQR: 2.0-3.2); 58 (59.8%) patients had primary tumor nodal metastasis. The median time from diagnosis of breast cancer to metastasectomy was 34 months (IQR: 16.8-61.3). The mean size of the largest liver lesion was 3.0 cm (2.0-5.0); half of patients (52.0%) had a solitary metastasis. An R0 resection was achieved in most cases (90.8%). Postoperative morbidity and mortality were 22.8% and 0%, respectively. Median and 3-year overall-survival was 53.4 months and 75.2%, respectively. On multivariable analysis, positive surgical margin (HR 3.57, 95% CI 1.40-9.16; p = 0.008) and diameter of the BCLM (HR 1.03, 95% CI 1.01-1.06; p = 0.002) remained associated with worse OS. DISCUSSION: In selected patients, resection of breast cancer liver metastases can be done safely and a subset of patients may derive a relatively long survival, especially from a margin negative resection.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationHPB (Oxford). 2016 Aug;18(8):700-5.pt_PT
dc.identifier.doi10.1016/j.hpb.2016.05.014pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3004
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAgedpt_PT
dc.subjectBreast Neoplasmspt_PT
dc.subjectDatabases, Factualpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectItalypt_PT
dc.subjectKaplan-Meier Estimatept_PT
dc.subjectLiver Neoplasmspt_PT
dc.subjectMargins of Excisionpt_PT
dc.subjectMetastasectomypt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMultivariate Analysispt_PT
dc.subjectPortugalpt_PT
dc.subjectProportional Hazards Modelspt_PT
dc.subjectRisk Factorspt_PT
dc.subjectTime Factorspt_PT
dc.subjectTreatment Outcomept_PT
dc.subjectTumor Burdenpt_PT
dc.subjectUnited Statespt_PT
dc.subjectHepatectomypt_PT
dc.subjectCHLC CHBPTpt_PT
dc.titleThe Role of Liver-Directed Surgery in Patients With Hepatic Metastasis From Primary Breast Cancer: a Multi-Institutional Analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage705pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage700pt_PT
oaire.citation.titleHPB (Oxford)pt_PT
oaire.citation.volume18pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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