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Dynamic Prediction of Survival After Curative Resection of Intrahepatic Cholangiocarcinoma: a Landmarking-Based Analysis

2022Journal article Open access
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dc.contributor.authorSpolverato, G
dc.contributor.authorCapelli, G
dc.contributor.authorLorenzoni, G
dc.contributor.authorGregori, D
dc.contributor.authorHe, J
dc.contributor.authorPopescu, I
dc.contributor.authorPinto Marques, H
dc.contributor.authorAldrighetti, L
dc.contributor.authorMaithel, S
dc.contributor.authorPulitano, C
dc.contributor.authorBauer, T
dc.contributor.authorShen, F
dc.contributor.authorPoultsides, G
dc.contributor.authorSoubrane, O
dc.contributor.authorMartel, G
dc.contributor.authorKoerkamp, B
dc.contributor.authorItaru, E
dc.contributor.authorLv, Y
dc.contributor.authorPawlik, T
dc.date.accessioned2024-04-16T14:56:54Z
dc.date.available2024-04-16T14:56:54Z
dc.date.issued2022
dc.description.abstractBackground: The current study aimed to develop a dynamic prognostic model for patients undergoing curative-intent resection for intrahepatic cholangiocarcinoma (ICC) using landmark analysis. Methods: Patients who underwent curative-intent surgery for ICC from 1999 to 2017 were selected from a multi-institutional international database. A landmark analysis to undertake dynamic overall survival (OS) prediction was performed. A multivariate Cox proportional hazard model was applied to measure the interaction of selected variables with time. The performance of the model was internally cross-validated via bootstrap resampling procedure. Discrimination was evaluated using the Harrell's Concordance Index. Accuracy was evaluated with calibration plots. Results: Variables retained in the multivariable Cox regression OS model included age, tumor size, margin status, morphologic type, histologic grade, T and N category, and tumor recurrence. The effect of several variables on OS changed over time. Results were provided as a survival plot and the predicted probability of OS at the desired time in the future. For example, a 65-year-old patient with an intraductal, T1, grade 3 or 4 ICC measuring 3 cm who underwent an R0 resection had a calculated estimated 3-year OS of 76%. The OS estimate increased if the patient had already survived 1 year (79%). The discrimination ability of the final model was very good (C-index: 0.80). Conclusion: The long-term outcome for patients undergoing curative-intent surgery for ICC should be adjusted based on follow-up time and intervening events. The model in this study showed excellent discriminative ability and performed well in the validation process.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAnn Surg Oncol . 2022 Nov;29(12):7634-7641.pt_PT
dc.identifier.doi10.1245/s10434-022-12156-1pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4878
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectHCC CIRpt_PT
dc.subjectAgedpt_PT
dc.subjectHumanspt_PT
dc.subjectBile Duct Neoplasms* / pathologypt_PT
dc.subjectBile Ducts, Intrahepatic / pathologypt_PT
dc.subjectCholangiocarcinoma* / pathologypt_PT
dc.subjectHepatectomypt_PT
dc.subjectNeoplasm Recurrence, Local / surgerypt_PT
dc.subjectPrognosispt_PT
dc.titleDynamic Prediction of Survival After Curative Resection of Intrahepatic Cholangiocarcinoma: a Landmarking-Based Analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage7641pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage7634pt_PT
oaire.citation.titleAnnals of Surgical Oncologypt_PT
oaire.citation.volume29pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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