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Nocturnal Blood Pressure Dipping in Acute Ischemic Stroke

2015-11Journal article Open access
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dc.contributor.authorSargento-Freitas, J
dc.contributor.authorLaranjinha, I
dc.contributor.authorGalego, O
dc.contributor.authorRebelo-Ferreira, A
dc.contributor.authorMoura, B
dc.contributor.authorCorreia, M
dc.contributor.authorSilva, F
dc.contributor.authorMachado, C
dc.contributor.authorCordeiro, G
dc.contributor.authorCunha, L
dc.date.accessioned2017-01-11T10:02:08Z
dc.date.available2017-01-11T10:02:08Z
dc.date.issued2015-11
dc.description.abstractOBJECTIVES: We aim to assess the impact of early nocturnal blood pressure (BP) variation in the functional outcome of patients after an acute ischemic stroke. MATERIALS AND METHODS: We included consecutive stroke patients treated with intravenous thrombolysis (IVrtPA) in a tertiary stroke center. BP measurements were performed at regular intervals throughout day and night during the first 48 h after stroke onset, and subjects were divided into four dipping categories (extreme dippers, dippers, non-dippers, and reverse dippers). Recanalization was assessed by transcranial color-coded Doppler and/or angiographic CT. Hemorrhagic transformation was evaluated at 24 h follow-up CT scan. Functional outcome was evaluated at 3 months after stroke using the modified Rankin Scale. RESULTS: A total of 304 patients were included, mean age 72.80 ± 11.10 years. After 24 h of systolic BP monitoring, 30.59% were classified as reverse dippers, 39.14% as non-dippers, 19.10% as dippers, and 11.18% as extreme dippers. Multivariate analysis did not show an independent association of any dipping class with 3-month functional outcome. Hemorrhagic transformation was not uniform between dipping classes: 25.81% for reverse dippers, 14.29% for non-dippers, 15.52% for dippers, and 5.88% for extreme dippers, P = 0.033. CONCLUSIONS: Nocturnal BP dipping pattern is not associated with functional outcome at 3 months in acute stroke patients treated with IVrtPA. Hemorrhagic transformation was more frequent in reverse dippers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Neurol Scand. 2015 Nov;132(5):323-8pt_PT
dc.identifier.doi10.1111/ane.12402pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2602
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley and Sonspt_PT
dc.subjectBrain Ischemiapt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectStrokept_PT
dc.subjectBlood Pressurept_PT
dc.subjectCircadian Rhythmpt_PT
dc.subjectAcute Stroke Therapypt_PT
dc.subjectThrombolysispt_PT
dc.subjectHDE PEDpt_PT
dc.titleNocturnal Blood Pressure Dipping in Acute Ischemic Strokept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage328pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage323pt_PT
oaire.citation.volume132pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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