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Lower Atherosclerotic Burden in Familial Abdominal Aortic Aneurysm

dc.contributor.authorLuijtgaarden, K
dc.contributor.authorBastos Gonçalves, F
dc.contributor.authorHoeks, S
dc.contributor.authorValentijn, T
dc.contributor.authorStolker, R
dc.contributor.authorMajoor-Krakauer, D
dc.contributor.authorVerhagen, H
dc.contributor.authorRouwet, E
dc.date.accessioned2014-07-23T14:59:33Z
dc.date.available2014-07-23T14:59:33Z
dc.date.issued2014
dc.description.abstractOBJECTIVE: Despite the apparent familial tendency toward abdominal aortic aneurysm (AAA) formation, the genetic causes and underlying molecular mechanisms are still undefined. In this study, we investigated the association between familial AAA (fAAA) and atherosclerosis. METHODS: Data were collected from a prospective database including AAA patients between 2004 and 2012 in the Erasmus University Medical Center, Rotterdam, The Netherlands. Family history was obtained by written questionnaire (93.1% response rate). Patients were classified as fAAA when at least one affected first-degree relative with an aortic aneurysm was reported. Patients without an affected first-degree relative were classified as sporadic AAA (spAAA). A standardized ultrasound measurement of the common carotid intima-media thickness (CIMT), a marker for generalized atherosclerosis, was routinely performed and patients' clinical characteristics (demographics, aneurysm characteristics, cardiovascular comorbidities and risk factors, and medication use) were recorded. Multivariable linear regression analyses were used to assess the mean adjusted difference in CIMT and multivariable logistic regression analysis was used to calculate associations of increased CIMT and clinical characteristics between fAAA and spAAA. RESULTS: A total of 461 AAA patients (85% men, mean age, 70 years) were included in the study; 103 patients (22.3%) were classified as fAAA and 358 patients (77.7%) as spAAA. The mean (standard deviation) CIMT in patients with fAAA was 0.89 (0.24) mm and 1.00 (0.29) mm in patients with spAAA (P = .001). Adjustment for clinical characteristics showed a mean difference in CIMT of 0.09 mm (95% confidence interval, 0.02-0.15; P = .011) between both groups. Increased CIMT, smoking, hypertension, and diabetes mellitus were all less associated with fAAA compared with spAAA. CONCLUSIONS: The current study shows a lower atherosclerotic burden, as reflected by a lower CIMT, in patients with fAAA compared with patients with spAAA, independent of common atherosclerotic risk factors. These results support the hypothesis that although atherosclerosis is a common underlying feature in patients with aneurysms, atherosclerosis is not the primary driving factor in the development of fAAA.por
dc.identifier.citationJ Vasc Surg. 2014 Mar;59(3):589-93por
dc.identifier.urihttp://hdl.handle.net/10400.17/1859
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSociety for Vascular Surgerypor
dc.subjectHSM CIR VASCpor
dc.subjectAneurisma da Aorta Abdominalpor
dc.subjectDoenças das Artérias Carótidaspor
dc.subjectArtéria Carótida Comumpor
dc.subjectEspessura Íntima-Média da Carótidapor
dc.subjectDistribuição de Chi-Quadradopor
dc.subjectPredisposição Genética para a Doençapor
dc.subjectHereditariedadepor
dc.subjectModelos Logísticospor
dc.subjectAnálise Multivariadapor
dc.subjectHolandapor
dc.subjectRazão de Possibilidadespor
dc.subjectFenótipopor
dc.subjectPlaca Ateroscleróticapor
dc.subjectQuestionáriospor
dc.subjectEstudos Retrospectivospor
dc.subjectFactores de Riscopor
dc.titleLower Atherosclerotic Burden in Familial Abdominal Aortic Aneurysmpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage593por
oaire.citation.startPage589por
oaire.citation.titleJournal of Vascular Surgerypor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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