Publication
Inducibility of Atrial Fibrillation During Electrophysiologic Evaluation is Associated with Increased Dispersion of Atrial Refractoriness
| dc.contributor.author | Oliveira, MM | |
| dc.contributor.author | Nogueira da Silva, M | |
| dc.contributor.author | Timóteo, AT | |
| dc.contributor.author | Feliciano, J | |
| dc.contributor.author | Sousa, L | |
| dc.contributor.author | Santos, S | |
| dc.contributor.author | Silva-Carvalho, L | |
| dc.contributor.author | Cruz Ferreira, R | |
| dc.date.accessioned | 2011-12-15T15:23:09Z | |
| dc.date.available | 2011-12-15T15:23:09Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | The impact of atrial dispersion of refractoriness (Disp_A) in the inducibility and maintenance of atrial fibrillation (AF) has not been fully resolved. AIM: To study the Disp_A and the vulnerability (A_Vuln) for the induction of self-limited (<60 s) and sustained episodes of AF. METHODS AND RESULTS: Forty-seven patients with paroxysmal AF (PAF): 29 patients without structural heart disease and 18 with hypertensive heart disease. Atrial effective refractory period (ERP) was assessed at five sites--right atrial appendage and low lateral right atrium, high interatrial septum, proximal and distal coronary sinus. We compared three groups: group A - AF not inducible (n=13); group B - AF inducible, self-limited (n=18); group C - AF inducible, sustained (n=16). Age, lone AF, hypertension, left atrial and left ventricular (LV) dimensions, LV systolic function, duration of AF history, atrial flutter/tachycardia, previous antiarrhythmics, and Disp_A were analysed with logistic regression to determine association with A_Vuln for AF inducibility. The ERP at different sites showed no differences among the groups. Group A had a lower Disp_A compared to group B (47+/-20 ms vs 82+/-65 ms; p=0.002), and when compared to group C (47+/-20 ms vs 80+/-55 ms; p=0.008). There was no significant difference in Disp_A between groups B and C. By means of multivariate regression analysis, the only predictor of A_Vuln was Disp_A (p=0.04). Conclusion: In patients with PAF, increased Disp_A represents an electrophysiological marker of A_Vuln. Inducibility of both self-limited and sustained episodes of AF is associated with similar values of Disp_A. These findings suggest that the maintenance of AF is influenced by additional factors. | por |
| dc.identifier.citation | Int J Cardiol. 2009 Aug 14;136(2):130-5 | por |
| dc.identifier.uri | http://hdl.handle.net/10400.17/533 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Elsevier | por |
| dc.subject | Fibrilhação Auricular | por |
| dc.subject | Seio Coronário | por |
| dc.subject | Aurícula do Coração | por |
| dc.subject | Sistema de Condução Cardíaco | por |
| dc.subject | Septo Cardíaco | por |
| dc.subject | Modelos Logísticos | por |
| dc.subject | Análise Multivariada | por |
| dc.subject | Valor Preditivo dos Testes | por |
| dc.subject | Período Refractário Electrofisiológico | por |
| dc.subject | Índice de Gravidade da Doença | por |
| dc.title | Inducibility of Atrial Fibrillation During Electrophysiologic Evaluation is Associated with Increased Dispersion of Atrial Refractoriness | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 135 | por |
| oaire.citation.startPage | 130 | por |
| oaire.citation.title | International Journal of Cardiology | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |