Publication
Long-Term Recurrence of Nonmelanoma Skin Cancer after Topical Methylaminolevulinate Photodynamic Therapy in a Dermato-Oncology Department
| dc.contributor.author | Cabete, J | |
| dc.contributor.author | Rafael, M | |
| dc.contributor.author | Cravo, M | |
| dc.contributor.author | Moura, C | |
| dc.contributor.author | Sachse, F | |
| dc.contributor.author | Pecegueiro, M | |
| dc.date.accessioned | 2016-01-15T10:54:17Z | |
| dc.date.available | 2016-01-15T10:54:17Z | |
| dc.date.issued | 2015-12 | |
| dc.description.abstract | BACKGROUND: Most available studies on the efficacy of topical photodynamic therapy focus on short-to medium-term results. Long-term data are scarce. OBJECTIVE: To evaluate the long-term efficacy of photodynamic therapy with topical methylaminolevulinate to treat Bowen's disease and basal cell carcinoma in the clinical practice setting of a dermato-oncology department. METHODS: The study included patients diagnosed with Bowen's disease or basal cell carcinoma, and who received photodynamic therapy from 2004 to 2008. Treatment protocol and clinical follow-up were standardized. The primary endpoint was clinically observed recurrence in a previous photodynamic therapy-treated area. Descriptive and survival analyses were performed. RESULTS: A total of 31 Bowen's disease lesions and 44 superficial basal cell carcinoma were treated, with a median follow-up of 43.5 months. Recurrence was observed in 14 Bowen's disease lesions (53.8%) and in 11 superficial basal cell carcinoma (33.3%). Significantly higher estimates for recurrence rates were found in patients with Bowen's disease (p=0.0036) or those aged under 58 years (p=0.039). The risk of recurrence was higher in patients with Bowen's disease than in those with superficial basal cell carcinoma and younger patients. CONCLUSIONS: Recurrence should be considered when choosing to treat non-melanoma skin cancer with photodynamic therapy. Younger age and Bowen's disease were independent predictors for long-term recurrence, suggesting the need to establish an extended period of follow-up for this subset of patients. | pt_PT |
| dc.identifier.citation | An Bras Dermatol. 2015 Dec;90(6):846-50 | pt_PT |
| dc.identifier.doi | 10.1590/abd1806-4841.20154080 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/2357 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Scielo | pt_PT |
| dc.subject | HSAC DER | pt_PT |
| dc.subject | Administration, Cutaneous | pt_PT |
| dc.subject | Age Factors | pt_PT |
| dc.subject | Aminolevulinic Acid/analogs & derivatives | pt_PT |
| dc.subject | Aminolevulinic Acid/therapeutic use | |
| dc.subject | Bowen's Disease/drug therapy | |
| dc.subject | Carcinoma, Basal Cell/drug therapy | |
| dc.subject | Follow-Up Studies | |
| dc.subject | Neoplasm Recurrence, Local | |
| dc.subject | Photochemotherapy/methods | |
| dc.subject | Photosensitizing Agents/therapeutic use | |
| dc.subject | Retrospective Studies | |
| dc.subject | Risk Assessment | |
| dc.subject | Skin Neoplasms/drug therapy | |
| dc.subject | Statistics, Nonparametric | |
| dc.subject | Time Factors | |
| dc.subject | Treatment Outcome | |
| dc.title | Long-Term Recurrence of Nonmelanoma Skin Cancer after Topical Methylaminolevulinate Photodynamic Therapy in a Dermato-Oncology Department | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 850 | pt_PT |
| oaire.citation.startPage | 846 | pt_PT |
| oaire.citation.title | Anais Brasileiros de Dermatologia | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |