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Magnetic Resonance Imaging Target Fusion Biopsy vs. Transrectal Ultrasound-Guided Biopsy - A Comparative Study of ISUP Score Upgrading Risk in the Final Radical Prostatectomy Specimen

2022Journal article Open access
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dc.contributor.authorGuimarães, T
dc.contributor.authorGil, M
dc.contributor.authorMedeiros, M
dc.contributor.authorAndrade, V
dc.contributor.authorGuerra, J
dc.contributor.authorPinheiro, H
dc.contributor.authorFernandes, F
dc.contributor.authorPina, J
dc.contributor.authorLopes Dias, J
dc.contributor.authorCampos Pinheiro, L
dc.date.accessioned2022-12-22T14:06:47Z
dc.date.available2022-12-22T14:06:47Z
dc.date.issued2022
dc.description.abstractObjectives: The aim of this study was to com-pare the risk of International Society of Urological Pathology (ISUP) score upgrading between magnetic resonance imaging targeted fusion biopsy (MRI-TB) and tran-srectal ultrasound-guided biopsy (TRUS-B) in the final radical prostatectomy (RP) specimen pathological report. Materials and methods: This retrospective single center study included 51 patients with prostate cancer (PCa) diagnosed with MRI-TB and 83 patients diagnosed with TRUS-B between October/2019 and July/2021. We compared the rates of ISUP score upgrading between both groups after robotic-assisted radi-cal prostatectomy (RARP) and the specific transition of each ISUP score based on biopsy modality. The rate of ISUP score concordance and downgrading were also assessed. To define the intra and interobserver concordance for each ISUP score in biopsy and RP specimen for each biopsy modality, the Cohen's Kappa coefficient was calculated. ISUP scores and biopsy modal-ity were selected for multivariate analysis and a logistic regres-sion model was built to provide independent risk factors of ISUP score upgrading. Results: The difference of the rate of upgrading between MRI-TB group and TRUS-B group was statistically significant (p = 0.007) with 42.2% of patients of TRUS-B group experiencing an upgrade in their ISUP score while only 19.6% in MRI-TB group. Concordance and downgrading rates did not statistically differ between the two groups. Strength of concordance using Cohen's Kappa coefficient was fair in both groups but higher in MRI-TB group (TRUS-B group k = 0.230; p < 0.001; concordance: 47%vs. MRI/TB group k = 0.438; p < 0.001; concordance: 62.7%). Biopsy modality and ISUP 1 on biopsy were independent predic-tors of ISUP upgrading after RP. Conclusions: MRI-TB is highly accurate with lower risk of PCa upgrading after RP than TRUS-B. Patients with ISUP 1 on biopsy have greater susceptibility to upgrading their ISUP score.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArch Ital Urol Androl . 2022 Sep 26;94(3):278-284.pt_PT
dc.identifier.doi10.4081/aiua.2022.3.278.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4322
dc.language.isoengpt_PT
dc.publisherPagepress Publicationspt_PT
dc.subjectCHLC UROpt_PT
dc.subjectCHLC IMApt_PT
dc.subjectBiopsypt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectImage-Guided Biopsy / methodspt_PT
dc.subjectMagnetic Resonance Imagingpt_PT
dc.subjectNeoplasm Gradingpt_PT
dc.subjectProstatectomy* / methodspt_PT
dc.subjectProstatic Neoplasms* / pathologypt_PT
dc.subjectProstatic Neoplasms* / surgerypt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectUltrasonography, Interventionalpt_PT
dc.titleMagnetic Resonance Imaging Target Fusion Biopsy vs. Transrectal Ultrasound-Guided Biopsy - A Comparative Study of ISUP Score Upgrading Risk in the Final Radical Prostatectomy Specimenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage284pt_PT
oaire.citation.startPage278pt_PT
oaire.citation.titleArchivio Italiano di Urologia e Andrologiapt_PT
oaire.citation.volume94pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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