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Positive Fluid Balance Was Associated with Mortality in Patients with Acute-on-Chronic Liver Failure: a Cohort Study

2021Journal article Open access
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dc.contributor.authorSousa Cardoso, F
dc.contributor.authorPereira, R
dc.contributor.authorLaranjo, A
dc.contributor.authorGamelas, V
dc.contributor.authorBagulho, L
dc.contributor.authorGermano, N
dc.contributor.authorKarvellas, C
dc.date.accessioned2022-12-07T16:14:05Z
dc.date.available2022-12-07T16:14:05Z
dc.date.issued2021
dc.description.abstractPurpose: We aimed to study the effect of FB in the outcomes of critically-ill patients with cirrhosis. Materials: Retrospective analysis of all adult consecutive admissions of patients with cirrhosis and organ failures to the Intensive Care Unit (ICU) at Curry Cabral Hospital (Lisbon, Portugal) and University of Alberta Hospital (Edmonton, Canada) on 08/2013-08/2017. Primary exposure was FB at 3 and 7 days post ICU admission. Primary endpoint was hospital mortality. Results: Amongst 333 patients, median age was 56 years and 67.6% were men. Median MELD, APACHEII, CLIF-SOFA, and CLIF-C-ACLF scores on ICU admission were 27, 28, 14, and 54, respectively. ICU and hospital mortality rates were 33.0% and 49.2%, respectively. While median FB at 3 days post ICU admission (+5.46 l vs. +6.62 l; P = 0.74) was not associated with hospital mortality, higher median FB at 7 days post ICU admission (+13.50 l vs. +6.90 l; P = 0.036) was associated with higher hospital mortality. This association remained significant (OR 95%CI = 1.04 [1.01;1.07] per each l) after adjustment for confounders (age, ascites, infection, lactate, and number of organ failures). Conclusions: FB may be a therapeutic target that helps to improve the outcomes of patients with acute-on-chronic liver failure. This data may inform future clinical trials.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Crit Care. 2021 Jun;63:238-242pt_PT
dc.identifier.doi10.1016/j.jcrc.2020.09.012.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4309
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectHCC CIRpt_PT
dc.subjectHCC GASpt_PT
dc.subjectHCC UCIpt_PT
dc.subjectHumanspt_PT
dc.subjectAdultpt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectAcute-On-Chronic Liver Failure*pt_PT
dc.subjectCohort Studiespt_PT
dc.subjectIntensive Care Unitspt_PT
dc.subjectPrognosispt_PT
dc.subjectLiver Cirrhosispt_PT
dc.subjectROC Curvept_PT
dc.subjectOrgan Dysfunction Scorespt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectWater-Electrolyte Balancept_PT
dc.titlePositive Fluid Balance Was Associated with Mortality in Patients with Acute-on-Chronic Liver Failure: a Cohort Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage242pt_PT
oaire.citation.startPage238pt_PT
oaire.citation.titleJournal of Critical Carept_PT
oaire.citation.volume63pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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