Repository logo
 
Publication

Cognitive Impairment and Magnetic Resonance Imaging Correlates in Primary Progressive Multiple Sclerosis

2017Journal article Open access
Simple item page
dc.contributor.authorGouveia, A
dc.contributor.authorDias, S
dc.contributor.authorSantos, T
dc.contributor.authorRocha, H
dc.contributor.authorCoelho, C
dc.contributor.authorRuano, L
dc.contributor.authorGalego, O
dc.contributor.authorDiogo, M
dc.contributor.authorSeixas, D
dc.contributor.authorSá, MJ
dc.contributor.authorBatista, S
dc.date.accessioned2022-12-21T16:14:05Z
dc.date.available2022-12-21T16:14:05Z
dc.date.issued2017
dc.description.abstractObjectives: To characterize cognitive impairment in primary progressive multiple sclerosis (PPMS) and to correlate the pattern of cognitive deficits with brain magnetic resonance imaging (MRI) volumetric data. Materials and methods: In a multicenter cross-sectional study, we recruited consecutive patients with PPMS as well as age, sex, and education level-matched healthy controls (HC). All participants underwent neuropsychological (NP) assessment, and brain MRI was performed in patients with PPMS for analysis of lesion load, subcortical GM volumes, and regional cortical volumes. Results: We recruited 55 patients with PPMS and 36 HC. Thirty-six patients were included in the MRI analysis. Patients with PPMS performed significantly worse than HC in all NP tests. Subcortical GM volume was significantly correlated with all NP tests, except for Stroop Test, with the largest effect for the thalamus (r=-.516 [BVMT-R DR, P=.016 FDR-corrected] to r=.664 [SDMT, P<.001 FDR-corrected]). In the stepwise linear regression model, thalamic volume was the only predictor of performance in all NP tests. Conclusion: Cognitive impairment is common in PPMS and affects all evaluated cognitive domains. Subcortical GM volume, particularly of the thalamus, is a strong predictor of cognitive performance, suggesting it has a central role in the pathophysiology of PPMS-related cognitive dysfunction.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Neurol Scand . 2017 Aug;136(2):109-115.pt_PT
dc.identifier.doi10.1111/ane.12702.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4314
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectCHLC NEUpt_PT
dc.subjectCHLC NRADpt_PT
dc.subjectAdultpt_PT
dc.subjectFemalept_PT
dc.subjectMalept_PT
dc.subjectHumanspt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectCognitive Dysfunction / diagnostic imaging*pt_PT
dc.subjectCognitive Dysfunction / epidemiologypt_PT
dc.subjectCognitive Dysfunction / psychology*pt_PT
dc.subjectCross-Sectional Studiespt_PT
dc.subjectMagnetic Resonance Imaging* / methodspt_PT
dc.subjectMultiple Sclerosis, Chronic Progressive / diagnostic imaging*pt_PT
dc.subjectMultiple Sclerosis, Chronic Progressive / epidemiologypt_PT
dc.subjectMultiple Sclerosis, Chronic Progressive / psychology*pt_PT
dc.subjectNeuropsychological Testspt_PT
dc.subjectThalamus / diagnostic imagingpt_PT
dc.titleCognitive Impairment and Magnetic Resonance Imaging Correlates in Primary Progressive Multiple Sclerosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage115pt_PT
oaire.citation.startPage109pt_PT
oaire.citation.titleActa Neurologica Scandinavicapt_PT
oaire.citation.volume136pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Acta Neurol Scand 109.pdf
Size:
487.48 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

NEU - Artigos
NRAD - Artigos