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Low Prevalence of Fetal-Type Posterior Cerebral Artery in Patients with Basilar Tip Aneurysms

2016-06-30Journal article Open access
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dc.contributor.authorDiogo, M
dc.contributor.authorFragata, I
dc.contributor.authorDias, SP
dc.contributor.authorNunes, J
dc.contributor.authorPamplona, J
dc.contributor.authorReis, J
dc.date.accessioned2017-06-08T15:51:14Z
dc.date.available2017-06-08T15:51:14Z
dc.date.issued2016-06-30
dc.description.abstractBACKGROUND: Basilar tip aneurysms (BTA) are multifactorial in origin, with luminal forces playing a major role in their formation. Considering the reduced hemodynamic stress on the basilar apex in the fetal-type posterior cerebral artery (fPCA), we hypothesize that BTA should be less common in patients with this variant. OBJECTIVE: To investigate, in a retrospective case-control study, the frequency of fPCA in patients with and without BTA. MATERIALS AND METHODS: We collected clinical and imaging data from consecutive patients with BTA undergoing catheter angiography between July 2010 and July 2015, and from a randomly selected, age- and sex-matched non-BTA control population from our prospective database. Anatomical variants of the distal basilar artery region were assessed in the two groups and compared using parametric and non-parametric tests. RESULTS: Fifty-nine BTA cases and 337 controls were included. fPCA was present in 3% of patients with BTA and 23% in the control group (p<0.001; OR=0.11, 95% CI 0.03 to 0.48). Basilar tip disposition was cranial in 49% of BTA and 63% of non-BTA cases (p=0.04; OR=0.57, 95% CI 0.33 to 0.99); a caudal disposition was found in 24% and 6% of cases, respectively (p<0.001; OR=4.65, 95% CI 2.21 to 9.80). CONCLUSIONS: We found a statistically significant association between the absence of fPCA and BTA. Our findings underline the importance of hemodynamic stress in the formation of intracranial aneurysms, and suggest that fPCA is a protective variant for formation of BTA.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Neurointerv Surg. 2016 Jun 30. pii: neurintsurg-2016-012503pt_PT
dc.identifier.doi10.1136/neurintsurg-2016-012503pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2701
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.subjectCHLC NRADpt_PT
dc.subjectCHLC NEUpt_PT
dc.subjectBasilar Artery/diagnostic imagingpt_PT
dc.subjectCase-Control Studiespt_PT
dc.subjectCerebral Angiography/methodspt_PT
dc.subjectHemodynamics/physiologypt_PT
dc.subjectIntracranial Aneurysm/diagnostic imagingpt_PT
dc.subjectIntracranial Aneurysm/epidemiology
dc.subjectPosterior Cerebral Artery/diagnostic imaging
dc.subjectPrevalence
dc.subjectProspective Studies
dc.subjectRetrospective Studies
dc.titleLow Prevalence of Fetal-Type Posterior Cerebral Artery in Patients with Basilar Tip Aneurysmspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of NeuroInterventional Surgerypt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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