Repository logo
 
Publication

Helicobacter Pylori Infection in Pediatric Patients Living in Europe: Results of the EuroPedHP Registry 2013 to 2016

2020Journal article Open access
Simple item page
dc.contributor.authorKori, M
dc.contributor.authorLe Thi, TG
dc.contributor.authorWerkstetter, K
dc.contributor.authorSustmann, A
dc.contributor.authorBontems, P
dc.contributor.authorLopes, AI
dc.contributor.authorOleastro, M
dc.contributor.authorIwanczak, B
dc.contributor.authorKalach, N
dc.contributor.authorMisak, Z
dc.contributor.authorCabral, J
dc.contributor.authorHoman, M
dc.contributor.authorCilleruelo Pascual, ML
dc.contributor.authorPehlivanoglu, E
dc.contributor.authorCasswall, T
dc.contributor.authorUrruzuno, P
dc.contributor.authorMartinez Gomez, MJ
dc.contributor.authorPapadopoulou, A
dc.contributor.authorRoma, E
dc.contributor.authorDolinsek, J
dc.contributor.authorRogalidou, M
dc.contributor.authorUrbonas, V
dc.contributor.authorChong, S
dc.contributor.authorKindermann, A
dc.contributor.authorMiele, E
dc.contributor.authorRea, F
dc.contributor.authorCseh, A
dc.contributor.authorKoletzko, S
dc.date.accessioned2021-06-24T09:09:17Z
dc.date.available2021-06-24T09:09:17Z
dc.date.issued2020
dc.description.abstractObjectives: The aim of the study was to assess clinical presentation, endoscopic findings, antibiotic susceptibility and treatment success of Helicobacter pylori (H. pylori) infected pediatric patients. Methods: Between 2013 and 2016, 23 pediatric hospitals from 17 countries prospectively submitted data on consecutive H. pylori-infected (culture positive) patients to the EuroPedHP-Registry. Results: Of 1333 patients recruited (55.1% girls, median age 12.6 years), 1168 (87.6%) were therapy naïve (group A) and 165 (12.4%) had failed treatment (group B). Patients resided in North/Western (29.6%), Southern (34.1%) and Eastern Europe (23.0%), or Israel/Turkey (13.4%). Main indications for endoscopy were abdominal pain or dyspepsia (81.2%, 1078/1328). Antral nodularity was reported in 77.8% (1031/1326) of patients, gastric or duodenal ulcers and erosions in 5.1% and 12.8%, respectively. Primary resistance to clarithromycin (CLA) and metronidazole (MET) occurred in 25% and 21%, respectively, and increased after failed therapy. Bacterial strains were fully susceptible in 60.5% of group A, but in only 27.4% of group B. Primary CLA resistance was higher in Southern and Eastern Europe (adjusted odds ratio [ORadj] = 3.44, 95% confidence interval [CI] 2.22-5.32, P < 0.001 and 2.62, 95% CI: 1.63-4.22, P < 0.001, respectively) compared with Northern/Western Europe. Children born outside Europe showed higher primary MET resistance (ORadj = 3.81, 95% CI: 2.25-6.45, P < 0.001). Treatment success in group A reached only 79.8% (568/712) with 7 to 14 days triple therapy tailored to antibiotic susceptibility. Conclusions: Peptic ulcers are rare in dyspeptic H. pylori-infected children. Primary resistance to CLA and MET is markedly dependent on geographical regions of birth and residence. The ongoing survey will show whether implementation of the updated ESPGHAN/NASPGHAN guidelines will improve the eradication success.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Pediatr Gastroenterol Nutr. 2020;71(4):476-483pt_PT
dc.identifier.doi10.1097/MPG.0000000000002816pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3749
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwer Healthpt_PT
dc.subjectAmoxicillinpt_PT
dc.subjectAnti-Bacterial Agentspt_PT
dc.subjectChildpt_PT
dc.subjectClarithromycinpt_PT
dc.subjectDrug Therapy, Combinationpt_PT
dc.subjectEuropept_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectIsraelpt_PT
dc.subjectMalept_PT
dc.subjectMetronidazolept_PT
dc.subjectRegistriespt_PT
dc.subjectTurkeypt_PT
dc.subjectHelicobacter Infectionspt_PT
dc.subjectHelicobacter pyloript_PT
dc.subjectHDE GAS PEDpt_PT
dc.titleHelicobacter Pylori Infection in Pediatric Patients Living in Europe: Results of the EuroPedHP Registry 2013 to 2016pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage483pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage476pt_PT
oaire.citation.titleJournal of pediatric gastroenterology and nutritionpt_PT
oaire.citation.volume71pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
J Ped Gastroenterol Nutr 2020_71_76.pdf
Size:
193.2 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

GAS PED - Artigos