Publication
Bone Marrow Granulomatosis in Acute Q Fever
| dc.contributor.author | Azevedo Carvalho, J | |
| dc.contributor.author | Pereira, S | |
| dc.contributor.author | Boavida, L | |
| dc.contributor.author | Gião, N | |
| dc.contributor.author | Bastos Furtado, A | |
| dc.date.accessioned | 2021-11-10T15:11:46Z | |
| dc.date.available | 2021-11-10T15:11:46Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Reported cases of Q fever in people living in urban areas after occasional contact with farm animals or infected pets such as dogs and cats have been increasing. The diagnosis of Q fever is usually laborious due to unspecific and variable clinical manifestations. The most common clinical presentation is an influenza-like illness with varying degrees of pneumonia and hepatitis. Acute hepatitis is more frequent than pneumonia in countries where the disease is endemic, such as in Portugal. We report a case of acute Q fever with hepatic and bone marrow involvement presented as fever of unknown origin (FUO) in a 56-year-old sportive hunter man. Typical fibrin ring granulomas (doughnut granulomas) were found in the bone marrow biopsy and were essential for the diagnosis. Bone marrow involvement is considered a rare manifestation of Q fever. Coxiella infection activates a granulomatous inflammatory response that can lead to persistent immune cell activation. Doughnut granulomas are not pathognomonic but they are highly specific for the diagnosis of Q fever. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Cureus 2021;13(10): e18782. | pt_PT |
| dc.identifier.doi | 10.7759/cureus.18782 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/3895 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | HSAC HEM | pt_PT |
| dc.subject | HSAC ANPAT | pt_PT |
| dc.subject | Fever | pt_PT |
| dc.subject | Q Fever | pt_PT |
| dc.subject | Fever of Unknown Origin | pt_PT |
| dc.subject | Fibrin | pt_PT |
| dc.subject | Coxiella Burnetii | pt_PT |
| dc.title | Bone Marrow Granulomatosis in Acute Q Fever | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Cureus | pt_PT |
| oaire.citation.volume | 13 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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