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Predicting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma

2021Journal article Open access
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dc.contributor.authorTsilimigras, DI
dc.contributor.authorSahara, K
dc.contributor.authorParedes, AZ
dc.contributor.authorMoro, A
dc.contributor.authorMehta, R
dc.contributor.authorMoris, D
dc.contributor.authorGuglielmi, A
dc.contributor.authorAldrighetti, L
dc.contributor.authorWeiss, M
dc.contributor.authorBauer, TW
dc.contributor.authorAlexandrescu, S
dc.contributor.authorPoultsides, GA
dc.contributor.authorMaithel, SK
dc.contributor.authorMarques, HP
dc.contributor.authorMartel, G
dc.contributor.authorPulitano, C
dc.contributor.authorShen, F
dc.contributor.authorSoubrane, O
dc.contributor.authorKoerkamp, BG
dc.contributor.authorEndo, I
dc.contributor.authorPawlik, TM
dc.date.accessioned2023-01-31T10:28:01Z
dc.date.available2023-01-31T10:28:01Z
dc.date.issued2021
dc.description.abstractBackground: The objective of the current study was to develop a model to predict the likelihood of occult lymph node metastasis (LNM) prior to resection of intrahepatic cholangiocarcinoma (ICC). Methods: Patients who underwent hepatectomy for ICC between 2000 and 2017 were identified using a multi-institutional database. A novel model incorporating clinical and preoperative imaging data was developed to predict LNM. Results: Among 980 patients who underwent resection of ICC, 190 (19.4%) individuals had at least one LNM identified on final pathology. An enhanced imaging model incorporating clinical and imaging data was developed to predict LNM ( https://k-sahara.shinyapps.io/ICC_imaging/ ). The performance of the enhanced imaging model was very good in the training data set (c-index 0.702), as well as the validation data set with bootstrapping resamples (c-index 0.701) and outperformed the preoperative imaging alone (c-index 0.660). The novel model predicted both 5-year overall survival (OS) (low risk 48.4% vs. high risk 18.4%) and 5-year disease-specific survival (DSS) (low risk 51.9% vs. high risk 25.2%, both p < 0.001). When applied among Nx patients, 5-year OS and DSS of low-risk Nx patients was comparable with that of N0 patients, while high-risk Nx patients had similar outcomes to N1 patients (p > 0.05). Conclusion: This tool may represent an opportunity to stratify prognosis of Nx patients and can help inform clinical decision-making prior to resection of ICC.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Gastrointest Surg . 2021 May;25(5):1156-1163pt_PT
dc.identifier.doi10.1007/s11605-020-04720-5pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4366
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerlinkpt_PT
dc.subjectLymph nodept_PT
dc.subjectMetastasispt_PT
dc.subjectIntrahepatic cholangiocarcinomapt_PT
dc.subjectHCC CIRpt_PT
dc.titlePredicting Lymph Node Metastasis in Intrahepatic Cholangiocarcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1163pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage1156pt_PT
oaire.citation.titleJournal of Gastrointestinal Surgerypt_PT
oaire.citation.volume25pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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