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HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed Patients in Portugal Between 2014 and 2019

2022-04Journal article Open access
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dc.contributor.authorPingarilho, M
dc.contributor.authorPimentel, V
dc.contributor.authorMiranda, M
dc.contributor.authorSilva, AR
dc.contributor.authorDiniz, A
dc.contributor.authorAscenção, B
dc.contributor.authorPiñeiro, C
dc.contributor.authorKoch, C
dc.contributor.authorRodrigues, C
dc.contributor.authorCaldas, C
dc.contributor.authorMorais, C
dc.contributor.authorFaria, D
dc.contributor.authorGomes da Silva, E
dc.contributor.authorTeófilo, E
dc.contributor.authorMonteiro, F
dc.contributor.authorRoxo, F
dc.contributor.authorMaltez, F
dc.contributor.authorRodrigues, F
dc.contributor.authorGaião, G
dc.contributor.authorRamos, H
dc.contributor.authorCosta, I
dc.contributor.authorGermano, I
dc.contributor.authorSimões, J
dc.contributor.authorOliveira, J
dc.contributor.authorFerreira, J
dc.contributor.authorPoças, J
dc.contributor.authorSaraiva da Cunha, J
dc.contributor.authorSoares, J
dc.contributor.authorHenriques, J
dc.contributor.authorMansinho, K
dc.contributor.authorPedro, L
dc.contributor.authorAleixo, MJ
dc.contributor.authorGonçalves, MaJ
dc.contributor.authorManata, MJ
dc.contributor.authorMouro, M
dc.contributor.authorSerrado, M
dc.contributor.authorCaixeiro, M
dc.contributor.authorMarques, N
dc.contributor.authorCosta, O
dc.contributor.authorPacheco, P
dc.contributor.authorProença, P
dc.contributor.authorRodrigues, P
dc.contributor.authorPinho, R
dc.contributor.authorTavares, R
dc.contributor.authorCorreia de Abreu, R
dc.contributor.authorCôrte-Real, R
dc.contributor.authorSerrão, R
dc.contributor.authorSarmento e Castro, R
dc.contributor.authorNunes, S
dc.contributor.authorFaria, T
dc.contributor.authorBaptista, T
dc.contributor.authorMartins, MR
dc.contributor.authorGomes, P
dc.contributor.authorMendão, L
dc.contributor.authorSimões, D
dc.contributor.authorAbecasis, A
dc.date.accessioned2023-03-17T16:09:51Z
dc.date.available2023-03-17T16:09:51Z
dc.date.issued2022-04
dc.description.abstractObjective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were used for subtyping, TDR determination, and transmission cluster (TC) analyses. Results: In Portugal, the overall prevalence of TDR between 2014 and 2019 was 11.0%. TDR presented a decreasing trend from 16.7% in 2014 to 9.2% in 2016 (p for-trend = 0.114). Multivariate analysis indicated that TDR was significantly associated with transmission route (MSM presented a lower probability of presenting TDR when compared to heterosexual contact) and with subtype (subtype C presented significantly more TDR when compared to subtype B). TC analysis corroborated that the heterosexual risk group presented a higher proportion of TDR in TCs when compared to MSMs. Among subtype A1, TDR reached 16.6% in heterosexuals, followed by 14.2% in patients infected with subtype B and 9.4% in patients infected with subtype G. Conclusion: Our molecular epidemiology approach indicates that the HIV-1 epidemic in Portugal is changing among risk group populations, with heterosexuals showing increasing levels of HIV-1 transmission and TDR. Prevention measures for this subpopulation should be reinforced.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Microbiol . 2022 Apr 25;13:823208.pt_PT
dc.identifier.doi10.3389/fmicb.2022.823208pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4463
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Media SApt_PT
dc.subjectHSJ MEDpt_PT
dc.subjectHSAC MEDpt_PT
dc.subjectHCC INFpt_PT
dc.subjectCHLC PAT CLINpt_PT
dc.subjectHIV-1pt_PT
dc.subjectPortugalpt_PT
dc.subjectTDRpt_PT
dc.subjectNewly Infected Patientspt_PT
dc.subjectTransmission Clusterspt_PT
dc.titleHIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed Patients in Portugal Between 2014 and 2019pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage823208pt_PT
oaire.citation.titleFrontiers in Microbiologypt_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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