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Influence of Human Milk on Very Preterms' Gut Microbiota and Alkaline Phosphatase Activity

2021Journal article Open access
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dc.contributor.authorMorais, J
dc.contributor.authorMarques, C
dc.contributor.authorFaria, A
dc.contributor.authorTeixeira, D
dc.contributor.authorBarreiros-Mota, I
dc.contributor.authorDurão, C
dc.contributor.authorAraújo, J
dc.contributor.authorIsmael, S
dc.contributor.authorBrito, S
dc.contributor.authorCardoso, M
dc.contributor.authorMacedo, I
dc.contributor.authorPereira, E
dc.contributor.authorTomé, T
dc.contributor.authorCalhau, C
dc.date.accessioned2022-06-15T15:05:39Z
dc.date.available2022-06-15T15:05:39Z
dc.date.issued2021
dc.description.abstractThe FEEDMI Study (NCT03663556) evaluated the influence of infant feeding (mother's own milk (MOM), donor human milk (DHM) and formula) on the fecal microbiota composition and alkaline phosphatase (ALP) activity in extremely and very preterm infants (≤32 gestational weeks). In this observational study, preterm infants were recruited within the first 24 h after birth. Meconium and fecal samples were collected at four time points (between the 2nd and the 26th postnatal days. Fecal microbiota was analyzed by RT-PCR and by 16S rRNA sequencing. Fecal ALP activity, a proposed specific biomarker of necrotizing enterocolitis (NEC), was evaluated by spectrophotometry at the 26th postnatal day. A total of 389 fecal samples were analyzed from 117 very preterm neonates. Human milk was positively associated with beneficial bacteria, such as Bifidobacterium, Bacteroides ovatus, and Akkermancia muciniphila, as well as bacterial richness. Neonates fed with human milk during the first week of life had increased Bifidobacterium content and fecal ALP activity on the 26th postnatal day. These findings point out the importance of MOM and DHM in the establishment of fecal microbiota on neonates prematurely delivered. Moreover, these results suggest an ALP pathway by which human milk may protect against NEC.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNutrients. 2021 May 6;13(5):1564.pt_PT
dc.identifier.doi10.3390/nu13051564.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4121
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.subjectMAC PEDpt_PT
dc.subjectMAC DIEpt_PT
dc.subjectHumanspt_PT
dc.subjectFemalept_PT
dc.subjectMalept_PT
dc.subjectAlkaline Phosphatase / metabolism*pt_PT
dc.subjectFeces / microbiologypt_PT
dc.subjectGastrointestinal Microbiome / physiology*pt_PT
dc.subjectGestational Agept_PT
dc.subjectInfant Formula / microbiologypt_PT
dc.subjectInfant Nutritional Physiological Phenomena / physiology*pt_PT
dc.subjectInfant, Newbornpt_PT
dc.subjectInfant, Extremely Premature / physiology*pt_PT
dc.subjectLongitudinal Studiespt_PT
dc.subjectMilk, Human / microbiology*pt_PT
dc.subjectRNA, Ribosomal, 16S / analysispt_PT
dc.titleInfluence of Human Milk on Very Preterms' Gut Microbiota and Alkaline Phosphatase Activitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage1564pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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