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Serum Tumor Markers Enhance the Predictive Power of the AJCC and LCSGJ Staging Systems in Resectable Intrahepatic Cholangiocarcinoma

2018Journal article Open access
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dc.contributor.authorSasaki, K
dc.contributor.authorMargonis, G
dc.contributor.authorAndreatos, N
dc.contributor.authorChen, Q
dc.contributor.authorBarbon, C
dc.contributor.authorBagante, F
dc.contributor.authorWeiss, M
dc.contributor.authorPopescu, I
dc.contributor.authorPinto Marques, H
dc.contributor.authorAldrighetti, L
dc.contributor.authorMaithel, S
dc.contributor.authorPulitano, C
dc.contributor.authorBauer, T
dc.contributor.authorShen, F
dc.contributor.authorPoultsides, G
dc.contributor.authorSoubrane, O
dc.contributor.authorMartel, G
dc.contributor.authorGroot Koerkamp, B
dc.contributor.authorGuglielmi, A
dc.contributor.authorEndo, I
dc.contributor.authorAucejo, F
dc.contributor.authorPawlik, T
dc.date.accessioned2021-03-19T17:32:29Z
dc.date.available2021-03-19T17:32:29Z
dc.date.issued2018
dc.description.abstractBackground: While several prognostic models have been developed to predict long-term outcomes in resectable intrahepatic cholangiocarcinoma (ICC), their prognostic discrimination remains limited. The addition of tumor markers might improve the prognostic power of the classification schemas proposed by the AJCC 8th edition and the Liver Cancer Study Group of Japan (LCSGJ). Methods: The prognostic discrimination of the AJCC and the LCSGJ were compared before and after the addition of CA 19-9 and CEA, using Harrell's C-index, net reclassification improvement (NRI) and the integrated discrimination improvement (IDI) in an international, multi-institutional cohort. Results: Eight hundred and five surgically treated patients with ICC that met the inclusion criteria were identified. On multivariable analysis, CEA5 ng/mL, 100IU/mL CA 19-9< 500IU/mL and CA 19-9500 IU/mL were associated with worse overall survival. The C-index of the AJCC and the LCSGJ improved from 0.540 to 0.626 and 0.553 to 0.626, respectively following incorporation of CA 19-9 and CEA. The NRI and IDI metrics confirmed the superiority of the modified AJCC and LCSGJ, compared to the original versions. Conclusion: The inclusion of preoperative CA 19-9 and CEA in the AJCC and LCSGJ staging schemas may improve prognostic discrimination among surgically treated patients with ICC.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationHPB (Oxford). 2018 Oct;20(10):956-965.pt_PT
dc.identifier.doi10.1016/j.hpb.2018.04.005pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3621
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAgedpt_PT
dc.subjectAsiapt_PT
dc.subjectBile Duct Neoplasmspt_PT
dc.subjectCA-19-9 Antigenpt_PT
dc.subjectCarcinoembryonic Antigenpt_PT
dc.subjectCholangiocarcinomapt_PT
dc.subjectEuropept_PT
dc.subjectFemalept_PT
dc.subjectHepatectomypt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectNeoplasm Stagingpt_PT
dc.subjectNew South Walespt_PT
dc.subjectNorth Americapt_PT
dc.subjectPredictive Value of Testspt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectRisk Factorspt_PT
dc.subjectTime Factorspt_PT
dc.subjectTreatment Outcomept_PT
dc.subjectDecision Support Techniquespt_PT
dc.subjectHCC CIRpt_PT
dc.titleSerum Tumor Markers Enhance the Predictive Power of the AJCC and LCSGJ Staging Systems in Resectable Intrahepatic Cholangiocarcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage965pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage956pt_PT
oaire.citation.titleHPB: the official journal of the International Hepato Pancreato Biliary Associationpt_PT
oaire.citation.volume20pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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