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Unknown Primary Merkel Cell Carcinoma With Cutaneous Spread

2019-02-21Journal article Open access
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dc.contributor.authorBarreira, JV
dc.contributor.authorValejo Coelho, M
dc.contributor.authorRibeiro, C
dc.contributor.authorSemedo, M
dc.date.accessioned2021-03-17T16:02:31Z
dc.date.available2021-03-17T16:02:31Z
dc.date.issued2019-02-21
dc.description.abstractThe authors present the case of a woman in the seventh decade of life with medical history of: left nephrectomy for renal tuberculosis and non-Hodgkin's lymphoma treated with chemotherapy (QT) and radiotherapy. She presented with a 2-month history of non-tender, left inguinal lymph node enlargement. Positron Emission Tomography (PET)-CT -scanshowed hypermetabolic inguinal and retroperitoneal lymphadenopathies, no primary tumour. On the second dermatological examination a pink, 2 cm plaque on the anterior left knee was noted. The histopathological analysis revealed Merkel cell carcinoma. The patient underwent two lines of systemic QT, with life-threatening toxicities limiting treatment. Followed overwhelming disease progression with lymphoedema and numerous skin metastases in the left lower limb. The patient received palliative care until death. The rare incidence of such neoplasia and its uncommon clinical presentation justifies reporting this case and highlights the importance of multidisciplinary teams in the management of cancer patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMJ Case Rep. 2019 Feb 21;12(2):e224834.pt_PT
dc.identifier.doi10.1136/bcr-2018-224834pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3600
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.subjectAgedpt_PT
dc.subjectAntineoplastic Combined Chemotherapy Protocolspt_PT
dc.subjectCarcinoma, Merkel Cellpt_PT
dc.subjectCombined Modality Therapypt_PT
dc.subjectDisease Progressionpt_PT
dc.subjectFatal Outcomept_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectKneept_PT
dc.subjectNeoplasms, Unknown Primarypt_PT
dc.subjectPalliative Carept_PT
dc.subjectPositron-Emission Tomographypt_PT
dc.subjectRadiotherapy, Adjuvantpt_PT
dc.subjectSkin Neoplasmspt_PT
dc.subjectHSAC ONCpt_PT
dc.subjectCHLC DERpt_PT
dc.titleUnknown Primary Merkel Cell Carcinoma With Cutaneous Spreadpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPagee224834pt_PT
oaire.citation.titleBMJ Case Reportspt_PT
oaire.citation.volume12pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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