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Disturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma Patients

2012Journal article Open access
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dc.contributor.authorAbegão Pinto, L
dc.contributor.authorVandewalle, E
dc.contributor.authorStalmans, I
dc.date.accessioned2015-10-08T16:07:42Z
dc.date.available2015-10-08T16:07:42Z
dc.date.issued2012
dc.description.abstractPURPOSE: (i) To investigate whether pulsatility index (PI) and mean flow velocities (MFV) are altered in glaucoma patients. (ii) To evaluate the significance of PI in retrobulbar autoregulation capacity. METHODS: Patients with primary open-angle glaucoma (POAG; n = 49), normal tension glaucoma (NTG; n = 62) and healthy controls (n = 48) underwent colour Doppler imaging measurements of the retrobulbar vasculature. Kruskal-Wallis test was used to compare variables between the three diagnostic groups. Restricted cubic splines were used to determine nonlinearities between the resistive index (RI) and PI correlations. RESULTS: Mean flow velocities (MFV) were lower in both short posterior ciliary arteries (SCPA) and central retinal arteries (CRA) from the two glaucoma groups (p < 0.04 versus healthy controls). No differences were detected in RI or PI in any arteries of the three diagnostic groups (p > 0.08). In healthy individuals, correlations between RI and PI were linear in all arteries. In both POAG and NTG patients, CRA presented a nonlinear curve with a cutpoint at RI 0.77 (p < 0.001) and 0.61 (p = 0.03), respectively, above which the slope increased nearly five- and tenfold (POAG: 1.96 to 10.06; NTG: -0.46-4.06), respectively. A nonlinear correlation in the ophthalmic artery was only observed in NTG patients, with a cutpoint at RI 0.82 (p < 0.001), above which the slope increased from 3.47 to 14.03. CONCLUSIONS: Glaucoma patients do not present the linear relationships between RI and PI observed in healthy individuals. Their nonlinear relations may be indicative of an altered autoregulation and suggest a possible threshold RI could be determined above which autoregulatory disturbances become more relevant.pt_PT
dc.identifier.citationActa Ophthalmol. 2012 May;90(3):e214-20pt_PT
dc.identifier.doi10.1111/j.1755-3768.2011.02335.x
dc.identifier.urihttp://hdl.handle.net/10400.17/2296
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectCHLC OFTpt_PT
dc.subjectBlood Flow Velocitypt_PT
dc.subjectBlood Pressure/physiologypt_PT
dc.subjectCiliary Arteries/physiologypt_PT
dc.subjectCiliary Arteries/ultrasonographypt_PT
dc.subjectGlaucoma, Open-Angle/physiopathologypt_PT
dc.subjectGlaucoma, Open-Angle/ultrasonographypt_PT
dc.subjectHomeostasispt_PT
dc.subjectIntraocular Pressure/physiologypt_PT
dc.subjectLow Tension Glaucoma/physiopathologypt_PT
dc.subjectLow Tension Glaucoma/ultrasonographypt_PT
dc.subjectOphthalmic Artery/physiologypt_PT
dc.subjectOphthalmic Artery/ultrasonographypt_PT
dc.subjectPulsatile Flowpt_PT
dc.subjectRegional Blood Flowpt_PT
dc.subjectRetinal Artery/physiologypt_PT
dc.subjectRetinal Artery/ultrasonographypt_PT
dc.subjectTonometry, Ocularpt_PT
dc.subjectUltrasonography, Doppler, Colorpt_PT
dc.subjectVisual Acuity/physiologypt_PT
dc.titleDisturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma Patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPagee220pt_PT
oaire.citation.startPagee214pt_PT
oaire.citation.titleActa Ophthalmologicapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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