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Anorectal Complications in Patients with Haematological Malignancies

2018Journal article Open access
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dc.contributor.authorLoureiro, R
dc.contributor.authorBorges, V
dc.contributor.authorTomé, AL
dc.contributor.authorBernardes, C
dc.contributor.authorSilva, M
dc.contributor.authorBettencourt, MJ
dc.date.accessioned2021-04-21T14:54:12Z
dc.date.available2021-04-21T14:54:12Z
dc.date.issued2018
dc.description.abstractBackground: Anorectal complications are common in patients with haematological malignancies. Objectives: The objectives are to characterize anorectal complications in these patients, identify risk factors and shed light on treatment, morbidity and mortality rates. Patients and methods: A retrospective, observational study that included 83 inpatients with haematological malignancies and proctological symptoms from January 2010 to September 2015 was conducted. Clinical outcomes were obtained through a detailed review of medical records. Results: The median age was 56 years, and 52 (62.7%) patients were men. Fifty-six (67.5%) patients had nonseptic anorectal complications and 27 (32.5%) patients had septic anorectal complications. Risks factors: Patients with septic anorectal complications were more commonly male, older, and had lower absolute neutrophil counts, but the differences were not statistically significant (P=0.79, 0.67 and 0.89, respectively). In positive blood cultures [23/70 (32.9%)], Enterococcus faecium, Klebsiella pneumonia, and Escherichia coli were the most common isolated agents. Treatment: In nonseptic anorectal complications, conservative treatments/minor proctological procedures were adopted, and patients with septic anorectal complications were treated with antibiotics±major proctological procedures and/or surgical drainage/debridement. Results of treatment: Forty-eight (85.7%) patients in the nonseptic complications group improved compared with 23 (85.2%) patients in the septic complications group. The overall mortality rate was 2.4% (n=2), with one (1.2%) death related to perianal sepsis. Conclusion: Enterococcus spp. were more commonly identified in this study and can be increasing in this specific population. In contrast to other reports, we did not identify an association between septic anorectal complications and possible risk factors such as male sex, younger age or a low absolute neutrophil count. Most patients had nonseptic anorectal complications. A major proctological procedure/surgical debridement should always be applied in septic complications, which have better prognoses now than in the past.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Gastroenterol Hepatol. 2018 Jul;30(7):722-726.pt_PT
dc.identifier.doi10.1097/MEG.0000000000001133pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3668
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwer Health, Inc.pt_PT
dc.subjectAdultpt_PT
dc.subjectAge Factorspt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectAnti-Bacterial Agentspt_PT
dc.subjectAnus Diseasespt_PT
dc.subjectBacterial Infectionspt_PT
dc.subjectDebridementpt_PT
dc.subjectDrainagept_PT
dc.subjectFemalept_PT
dc.subjectHematologic Neoplasmspt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMedical Recordspt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectRectal Diseasespt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectRisk Factorspt_PT
dc.subjectSepsispt_PT
dc.subjectSex Factorspt_PT
dc.subjectTreatment Outcomept_PT
dc.subjectYoung Adultpt_PT
dc.subjectHSAC GASpt_PT
dc.titleAnorectal Complications in Patients with Haematological Malignanciespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage726pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage722pt_PT
oaire.citation.titleEuropean Journal of Gastroenterology & Hepatologypt_PT
oaire.citation.volume30pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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