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COVID- 19 in Patients Affected by Red Blood Cell Disorders, Results From the European Registry ERN-EuroBloodNet.

2025-04-16Text Open access
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dc.contributor.authorPuyo, Pablo
dc.contributor.authorChristou, Soteroula
dc.contributor.authorCampisi, Saveria
dc.contributor.authorRodríguez-Sánchez, Maria A
dc.contributor.authorReidel, Sara
dc.contributor.authorPerez-Hoyo, Santiago
dc.contributor.authorMota, Miriam
dc.contributor.authorSavvidou, Irene
dc.contributor.authorRekleiti, Anna
dc.contributor.authorSalvo, Alessandra
dc.contributor.authorVoi, Vincenzo
dc.contributor.authorFerrero, Giovanni Battista
dc.contributor.authorMandrile, Giorgia
dc.contributor.authorGaglioti, Carmen Maria
dc.contributor.authorCela, Elena
dc.contributor.authorPonce-Salas, Beatriz
dc.contributor.authorBardón-Cancho, Eduardo J
dc.contributor.authorFlevari, Pagona
dc.contributor.authorVoskaridou-Dimoula, Ersi
dc.contributor.authorNur, Erfan
dc.contributor.authorBiemond, Bart J
dc.contributor.authorDelaporta, Polynexi
dc.contributor.authorBeneitez-Pastor, David
dc.contributor.authorCollado Gimbert, Anna
dc.contributor.authorSpasiano, Anna
dc.contributor.authorBesse-Hammer, Tatiana
dc.contributor.authorLafiatis, Ioannis G
dc.contributor.authorDedeken, Laurence
dc.contributor.authorRaso, Simona
dc.contributor.authorRuiz-Llobet, Anna
dc.contributor.authorBagnato, Sabrina
dc.contributor.authorLabarque, Veerle
dc.contributor.authorGlenthøj, Andreas
dc.contributor.authorRuffo, Giovan Battista
dc.contributor.authorGuerzoni, Maria Elena
dc.contributor.authorHafraoui, Kaoutar
dc.contributor.authorPistoia, Laura
dc.contributor.authorRosso, Rosamaria
dc.contributor.authorTagliaferri, Laura
dc.contributor.authorGonzalez-Urdiales, Paula
dc.contributor.authorBenghiat, Fleur Samantha
dc.contributor.authorde Montalembert, Mariane
dc.contributor.authorTeles, Maria Jose
dc.contributor.authorVanderfaeillie, Anna
dc.contributor.authorBertoni, Elisa
dc.contributor.authorCuzzubbo, Daniela
dc.contributor.authorFerreira, Teresa
dc.contributor.authorSaunders, Christopher J
dc.contributor.authorStiakaki, Eftichia
dc.contributor.authorVan de Velde, Ann L
dc.contributor.authorDiamantidis, Michael D
dc.contributor.authorKerkhoffs, Jean-Louis H
dc.contributor.authorOliveira, Marisa I
dc.contributor.authorQuota, Alessandra
dc.contributor.authorRusso, Roberta
dc.contributor.authorVan Damme, An
dc.contributor.authorArgüello Marina, María
dc.contributor.authorLorite Reggiori, Mikael
dc.contributor.authorRijneveld, Anita W
dc.contributor.authorRodríguez Gallego, Alexis
dc.contributor.authorColombatti, Raffaella
dc.contributor.authorIolascon, Achille
dc.contributor.authorTaher, Ali
dc.contributor.authorGulbis, Béatrice
dc.contributor.authorRoy, Noémi B A
dc.contributor.authorMañú-Pereira, María Del Mar
dc.date.accessioned2025-04-24T13:24:07Z
dc.date.available2025-04-24T13:24:07Z
dc.date.issued2025-04-16
dc.description.abstractBackground: Despite several publications covering patients from multiple centers, no international registry covered all patients with red blood cell diseases (RBCD) affected by COVID- 19. The ERN-EuroBloodNet's registry provided real-time registration of SARS-CoV- 2 patients with RBCD, promoting timely disease-specific knowledge sharing during the pandemic's early stages. Procedures: The study evaluated patient distribution, the infection across different RBCDs, and severity risk factors across similar healthcare systems, using data collected from the ERN-EuroBloodNet's REDCap platform. Results: From April 2020 to April 2023, 681 infections were recorded among 663 patients, of which 373 had transfusion-dependent thalassemia or non-transfusion-dependent thalassemia (TDT/NTDT), and 269 had sickle cell disease (SCD). SCD patients had a higher incidence of COVID- 19 than those with TDT/NTDT (10.5 vs. 4.8 COVID/100 patients). Notably, 92% of the cases were mild, with neither age nor the specific RBCD affecting severity. The number of comorbidities, notably obesity and hypertension, that patients had prior to infection was associated with more severe COVID- 19. During the infection, the presence of vaso-occlusive crises, acute chest syndrome, kidney failure, and ground-glass opacities on chest tomography scans were associated with a more severe clinical picture. The vaccination rate (32%) mirrored that of the general population and showed a protective effect against severe COVID- 19. The observed mortality rate was 0.7%, aligning with Europe's general population. Conclusion: SARS-CoV- 2 infection in SCD and TDT/NTDT patients is mild and without higher mortality than the general population. The ERN-Eurobloodnet's registry collaborative structure exemplifies the power of international cooperation in tackling rare diseases, especially during health emergencies.eng
dc.identifier.citationOrphanet J Rare Dis . 2025;20(1):183. doi: 10.1186/s13023-025-03683-7.
dc.identifier.doi10.1186/s13023-025-03683-7
dc.identifier.pmid40241127
dc.identifier.urihttp://hdl.handle.net/10400.17/5083
dc.language.isoeng
dc.peerreviewedyes
dc.publisherBMC
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectThalassemia
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectHSAC HEM
dc.subjectHDE HEM PED
dc.subjectChild
dc.subjectAnemia
dc.subjectSickle Cell* / complications
dc.subjectSickle Cell* / epidemiology
dc.subjectCOVID-19* / complications
dc.subjectCOVID-19* / epidemiology
dc.subjectPreschool
dc.subjectMale
dc.subjectFemale
dc.subjectHumans
dc.subjectEurope / epidemiology
dc.subjectMiddle Aged
dc.subjectRisk Factors
dc.subjectRegistries
dc.subjectYoung Adult
dc.subjectSARS-CoV-2
dc.subjectThalassemia* / complications
dc.subjectThalassemia* / epidemiology
dc.titleCOVID- 19 in Patients Affected by Red Blood Cell Disorders, Results From the European Registry ERN-EuroBloodNet.eng
dc.typetext
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.startPage183
oaire.citation.titleOrphanet Journal of Rare Diseases
oaire.citation.volume20
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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