Publication
Nivolumab-Induced Seronegative Encephalitis
| dc.contributor.author | Cabral, G | |
| dc.contributor.author | Ladeira, F | |
| dc.contributor.author | Gil, N | |
| dc.date.accessioned | 2024-02-22T15:48:32Z | |
| dc.date.available | 2024-02-22T15:48:32Z | |
| dc.date.issued | 2020-10 | |
| dc.description.abstract | Immune checkpoint inhibitors (ICIs) have emerged as a new therapeutic tool for numerous types of cancer. Neurological complications have been reported in 1% of patients who have undergone checkpoint inhibition therapy. ICIs-induced encephalitides occur in 0.1-0.2% of patients within weeks after ICIs initiation; are usually seronegative and have nonspecific changes on imaging, CSF and electroencephalogram (EEG) studies. Early recognition and prompt treatment are important to prevent significant morbidity and mortality. We present a case of nivolumab-induced encephalitis with very subtle clinical symptoms and full recovery following ICIs suspension and steroids. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | J Neuroimmunol . 2020 Oct 15:347:577350. | pt_PT |
| dc.identifier.doi | 10.1016/j.jneuroim.2020.577350 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/4811 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.subject | HSAC NEU | pt_PT |
| dc.subject | Aged | pt_PT |
| dc.subject | Female | pt_PT |
| dc.subject | Humans | pt_PT |
| dc.subject | Encephalitis / blood | pt_PT |
| dc.subject | Encephalitis / chemically induced* | pt_PT |
| dc.subject | Encephalitis / diagnostic imaging* | pt_PT |
| dc.subject | Immune Checkpoint Inhibitors / adverse effects* | pt_PT |
| dc.subject | Nivolumab / adverse effects* | pt_PT |
| dc.title | Nivolumab-Induced Seronegative Encephalitis | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.startPage | 577350 | pt_PT |
| oaire.citation.title | Journal of Neuroimmunology | pt_PT |
| oaire.citation.volume | 347 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |