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Language Improvement One Week After Thrombolysis in Acute Stroke

2017-03Journal article Open access
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dc.contributor.authorMartins, IP
dc.contributor.authorFonseca, J
dc.contributor.authorMorgado, J
dc.contributor.authorLeal, G
dc.contributor.authorFarrajota, L
dc.contributor.authorFonseca, AC
dc.contributor.authorMelo, TP
dc.date.accessioned2019-10-29T16:24:26Z
dc.date.available2019-10-29T16:24:26Z
dc.date.issued2017-03
dc.description.abstractOBJECTIVES: Language recovery following acute stroke is difficult to predict due to several evaluation factors and time constraints. We aimed to investigate the predictors of aphasia recovery and to identify the National Institute of Health and Stroke Scale (NIHSS) items that best reflect linguistic performance, 1 week after thrombolysis. MATERIALS AND METHODS: We retrieved data from a prospective registry of patients with aphasia secondary to left middle cerebral artery (MCA) stroke treated with intravenous thrombolysis. Complete recovery at day 7 (D7) was measured in a composite verbal score (CVS) (Σ Language+Questions+Commands NIHSS scores). Lesion size was categorized by the Alberta Stroke Program Early CT score (ASPECTS) and vascular patency by ultrasound. CVS was correlated with standardized aphasia testing if both were performed within a two-day interval. RESULTS: Of 228 patients included (age average 67.32 years, 131 men), 72% presented some language improvement that was complete in 31%. Total recovery was predicted by ASPECTS (OR=1.65; 95% CI, 1.295-2.108; P < 0.00) and baseline aphasia severity (OR=0.439; 95% CI, 0.242-0.796; P < 0.007). CVS correlated better with standardized aphasia measures (aphasia quotient, severity, comprehension) than NIHSS_Language item. CONCLUSIONS: Lesion size and initial aphasia severity are the main predictors of aphasia recovery one week after thrombolysis. A NIHSS composite verbal score seems to capture the global linguistic performance better than the language item alone.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Neurol Scand. 2017 Mar;135(3):339-345.pt_PT
dc.identifier.doi10.1111/ane.12604pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3342
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectAphasia/drug therapypt_PT
dc.subjectFemalept_PT
dc.subjectFibrinolytic Agents/administration & dosagept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectStroke/complicationspt_PT
dc.subjectOutcome Assessment (Health Care)pt_PT
dc.subjectRegistriespt_PT
dc.subjectCHLC NEUpt_PT
dc.subjectAphasia/etiology
dc.subjectFibrinolytic Agents/pharmacology
dc.subjectStroke/drug therapy
dc.titleLanguage Improvement One Week After Thrombolysis in Acute Strokept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage345pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage339pt_PT
oaire.citation.titleActa Neurologica Scandinavicapt_PT
oaire.citation.volume135pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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